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    Glossary Hair Root Cells

    specialized cells at the base of hair follicles

    Hair root cells are specialized cells located at the base of the hair follicle, within the hair bulb. These cells are responsible for the production and growth of hair by dividing and differentiating to form the hair shaft and its surrounding structures. They play a crucial role in the hair growth cycle, including phases of growth (anagen), regression (catagen), and rest (telogen).

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    1. Single-strand DNA breaks in human hair root cells exposed to mobile phone radiation International Journal of Radiation Biology · 2012 · 37 citations
    2. miR-140-5p in Small Extracellular Vesicles From Human Papilla Cells Stimulates Hair Growth by Promoting Proliferation of Outer Root Sheath and Hair Matrix Cells Frontiers in cell and developmental biology · 2020 · 18 citations
    3. Human Hair Outer Root Sheath Cells and Platelet-Lysis Exosomes Promote Hair Inductivity of Dermal Papilla Cell Tissue Engineering and Regenerative Medicine · 2020 · 9 citations
    4. Interferon β Secreted from Human Hair Dermal Papilla Cells Inhibits the Growth of Outer Root Sheath Cells Cultured in Vitro Biochemical and biophysical research communications · 2002 · 13 citations
    5. Outer root sheath cells secrete oxytocin for hair growth promotion and stem cell proliferation Journal of Bioscience and Bioengineering · 2026
    6. 18-β-Glycyrrhetinic Acid Promotes Hair Growth by Stimulating the Proliferation of Dermal Papilla Cells and Outer Root Sheath Cells, and Extends the Anagen Phase by Inhibiting 5α-Reductase Biological and Pharmaceutical Bulletin · 2024
    7. Solid basal cell epithelioma (BCE) possibly originates from the outer root sheath of the hair follicle. PubMed · 1993 · 61 citations
    8. Sex hormones and antiandrogens influence in vitro growth of dermal papilla cells and outer root sheath keratinocytes of human hair follicles 1993 · 9 citations
    9. Nestin as a marker of unipotent epithelial progenitor cells differentiate into outer root sheath keratinocytes in embryonic and adult hair follicles Research Square (Research Square) · 2022
    10. Nestin as a marker of unipotent epithelial progenitor cell differentiation into outer root sheath keratinocytes in embryonic and adult hair follicles Research Square (Research Square) · 2022
    11. A Novel Epithelial Keratin, hK6irs1, is Expressed Differentially in All Layers of the Inner Root Sheath, Including Specialized Huxley Cells (Flügelzellen) of the Human Hair Follicle Journal of Investigative Dermatology · 2002 · 86 citations
    12. In vitro effects of testosterone, dihydrotestosterone and estradiol on cell growth of human hair bulb papilla cells and hair root sheath fibroblasts. Acta Dermato Venereologica · 1990 · 22 citations
    13. Role of the Wnt/β-Catenin Signaling Pathway in Mediating Outer Root Sheath Stem Cells to Promote Hair Follicle Regeneration and Skin Wound Healing in Mice Cells · 2026
    14. Keratins of the human hair follicle: “Hyperproliferative” keratins consistently expressed in outer root sheath cells in vivo and in vitro Differentiation · 1987 · 135 citations
    15. Manipulation of outer root sheath cell survival perturbs the hair-growth cycle The EMBO Journal · 1999 · 37 citations
    16. VEGF165 modulates proliferation, adhesion, migration and differentiation of cultured human outer root sheath cells from central hair follicle epithelium through VEGFR-2 activation in vitro Journal of Dermatological Science · 2013 · 35 citations
    17. Structural features of the α-type filaments of the inner root sheath cells of the guinea pig hair follicle Biochemistry · 1978 · 24 citations
    18. Double-stranded RNA induces inflammation via the NF-κB pathway and inflammasome activation in the outer root sheath cells of hair follicles Scientific reports · 2017 · 22 citations
    19. Mesenchymal Stem Cells Antagonize IFN-Induced Proinflammatory Changes and Growth Inhibition Effects via Wnt/β-Catenin and JAK/STAT Pathway in Human Outer Root Sheath Cells and Hair Follicles International journal of molecular sciences · 2021 · 14 citations
    20. [An immunohistochemical study on cell differentiation in the outer root sheath of the normal human anagen hair follicles with antikeratin monoclonal antibodies]. PubMed · 1990 · 6 citations
    21. Cytochemistry of Trichohyalin Granules: A Possible Role for Cornification of Inner Root Sheath Cell in the Hair Follicle The Journal of Dermatology · 1989 · 4 citations
    22. 1332 Janus kinase inhibitor increases hair growth by increasing beta-catenin activity in outer root sheath cells 2023
    23. Experimental Modulation of the Differentiated Phenotype of Keratinocytes from Epidermis and Hair Follicle Outer Root Sheath and Matrix Cells Annals of the New York Academy of Sciences · 1991 · 31 citations
    24. Morus alba Root Extract Induces the Anagen Phase in the Human Hair Follicle Dermal Papilla Cells Pharmaceutics · 2021 · 28 citations
    25. Anti-oxidant Efficacy and Effects on Expression of Growth Factors in Human Hair Follicle Dermal Papilla Cells of Rosa multiflora Root Extracts Asian journal of beauty & cosmetology · 2017 · 6 citations
    26. The Auxin-Regulated CrRLK1L Kinase ERULUS Controls Cell Wall Composition during Root Hair Tip Growth 2018 · 109 citations
    27. Effects of epidermal growth factor, fibroblast growth factor, minoxidil and hydrocortisone on growth kinetics in human hair bulb papilla cells and root sheath fibroblasts cultured in vitro Archives of Dermatological Research · 1987 · 58 citations
    28. An endophytic microbe from an unusual volcanic swamp corn seeks and inhabits root hair cells to extract rock phosphate Scientific reports · 2017 · 26 citations
    29. Effects of Human Hair Outer Root Sheath Cell- and Human Bone Marrow Mesenchymal Stem Cell-Derived Exosomes on Human Hair Follicle Stem Cells Current Stem Cell Research & Therapy · 2026
    30. Faculty Opinions recommendation of Local positive feedback regulation determines cell shape in root hair cells. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2008