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research Pathobiology of chemotherapy-induced hair loss

218 citations , January 2013 in “The Lancet Oncology”

This review discusses the pathobiology of chemotherapy-induced alopecia and highlights challenges in managing it, reporting no new clinical results and emphasizing the need for well-designed preclinical models to develop effective treatments.

research Pathobiology of the hairless phenotype: Dysregulation of hair follicle apoptosis and topobiology during the initiation of follicle cycling

9 citations , March 1998 in “Journal of Dermatological Science”

Improper regulation of hair follicle processes causes hairlessness.

research Identifying critical cell types and gene regulatory pathways for hair and skin disease

July 2023 in “Nature Genetics”

Researchers identified key cell types and genes involved in hair and skin diseases.

research Alopecia in general medicine

13 citations , February 2016 in “Clinical Medicine”

This article discusses various types of alopecia relevant to hospital medicine and reports no new clinical findings, emphasizing the need for accurate diagnosis and understanding of associated psychological impacts.

Environmental Pathobiology of Frontal Fibrosing Alopecia: Does Linalool Promote FFA Development and Progression?

research 382 Environmental pathobiology of frontal fibrosing alopecia (FFA): Does linalool promote FFA development and progression by inducing epithelial hair follicle stem cell damage and MICA expression in the bulge?

November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study suggests that allergens like linalool found in personal care products may contribute to the pathobiology of frontal fibrosing alopecia by affecting immune responses and stem cell function in hair follicles.

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Community Join

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community Another theory for hair loss: Parasites in gut.

in Research/Science 9 months ago

Parasites in the gut may contribute to hair loss by depleting essential nutrients and disrupting hormone balance. An imbalance of hormones, not just DHT, could be a factor in androgenic alopecia.

community My Theory Of Androgenic Alopecia

16 upvotes 10 months ago

Hair loss is linked to cellular physiology and the IGF-1 to TGF-B1 ratio, not just androgen sensitivity. The theory lacks evidence, while finasteride and minoxidil are effective treatments.

community Gut microbiome imbalances linked to scalp inflammation and hair follicle impact

in Technology 243 upvotes 4 months ago

Gut microbiome imbalances can cause scalp inflammation and affect hair follicles, potentially leading to hair loss. Treatments include finasteride, peptides like BPC-157, TB-500, KPV, and lifestyle changes such as diet and exercise.

community The mechanism of androgenic alopecia

36 upvotes 11 months ago

DHT may inhibit hair growth by affecting mitochondrial function, leading to hair follicle miniaturization. Treatments like minoxidil and PP405 may promote hair growth by altering metabolic pathways, potentially counteracting DHT's effects.

community Genomic Sequencing for Hair Loss

in Research/Science 156 upvotes 5 months ago

Hair loss treatments like Minoxidil, finasteride, and potential mRNA therapies are discussed. There is skepticism about targeting specific genes due to the complex genetic nature of hair loss.

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Clinics

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Learn

6 / 801 results

learn Alopecia Areata

autoimmune disorder causing patchy hair loss

learn Valproic acid

an anticonvulsant repurposed for hair loss via histone inhibition

What biological mechanisms related to hair follicles are linked to valproic acid in experimental treatments? Valproic acid affects hair follicles by modulating cell signaling and gene regulation.

learn Hair Transplant

Hair transplantation moves DHT-resistant follicles from a donor area (back and sides of the scalp) into thinning or bald areas. The transplanted hair is generally permanent, though surrounding native hair can keep thinning.

What causes hair loss in women that may lead to considering a hair transplant? Genetic factors, hormonal changes, stress, and nutritional deficiencies often cause hair loss in women.
What causes male pattern baldness? Male pattern baldness is caused by genetic sensitivity to the hormone DHT.

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Vitamin D

What is the connection between Vitamin D and hair loss? Vitamin D deficiency may contribute to hair loss by disrupting hair follicle regulation.

learn zinc PCA

Can a zinc deficiency directly cause hair thinning or increased shedding? Studies link low serum zinc to diffuse shedding and alopecia areata, and severe deficiency states cause hair loss that reverses when zinc is replaced. The evidence is mostly observational, the one supplementation study was small and uncontrolled, and zinc is not a treatment for pattern hair loss.

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Experts

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SMP Specialist
Hairo Fallas
Newark, NJ, United States

Hairo Fallas