Protective Mechanism of Adipose-Derived Stem Cells in Remodeling of the Skin Stem Cell Niche During Photoaging

January 2018 in “ Cellular Physiology and Biochemistry ”

Meihua Gong, Pan Zhang, Chunyang Li, Xu Ma, Daping Yang

adipose-derived stem cells ADSCs UVB irradiation photoaging Bmp4 BMP signaling pathway hair follicles skin stem cell niche epidermal thickness Collagen IV fat stem cells UVB light skin aging bone morphogenetic protein 4 BMP pathway hair roots skin stem cell environment skin layer thickness Collagen 4

Studysummary This study found that UVB irradiation alters skin stem cell niches leading to signs of photoaging, which may be reversed by adipose-derived stem cells through BMP4 pathway modulation and niche remodeling.

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In the 2018 study, researchers found that UVB irradiation led to photoaging by decreasing the expression of Bmp4 and its downstream factors in the skin stem cell niche, which are crucial for the BMP signaling pathway in hair follicles. The study, which involved 64 C57BL/6J mice, showed that adipose-derived stem cells (ADSCs) treatment could reverse these effects. ADSCs increased the expression of Bmp4 and related factors, coexpressed skin stem cell markers, and could transdifferentiate into skin stem cells, suggesting their role in remodeling the skin stem cell niche and protecting against UVB-induced photoaging. The study concluded that ADSCs have a protective effect on the skin stem cell niche during photoaging by modulating the BMP signaling pathway, epidermal thickness, and expression of various aging-related factors, without significantly altering Collagen IV expression.

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