Chemoprevention of Doxorubicin-Induced Alopecia in Mice by Dietary Administration of L-Cystine and Vitamin B6

The study from 11 years ago explored the potential of L-cystine and vitamin B6 to prevent hair loss caused by the chemotherapy drug doxorubicin in mice. The researchers found that a high dosage of these supplements (1,600 mg/kg of L-cystine and 160 mg/kg of vitamin B6) provided complete protection against alopecia, while an intermediate dosage (800 mg/kg of L-cystine and 80 mg/kg of vitamin B6) offered partial protection. The lowest dosage tested did not prevent hair loss. Although the study showed promising results for the use of L-cystine and vitamin B6 in preventing chemotherapy-induced alopecia in mice, the applicability to humans requires further investigation, including clinical trials to establish effective dosages. The number of mice used in the study was not mentioned in the summary provided.