Hair Follicle-Derived Blood Vessels Vascularize Tumors in Skin and Are Inhibited by Doxorubicin
March 2005
in “
Cancer Research
”
TLDR Doxorubicin can block blood vessels from hair follicles, reducing skin tumor growth.
The study investigated the role of hair follicle-derived blood vessels in skin tumor vascularization and the effects of doxorubicin on this process. It was found that blood vessels from hair follicles contributed to the blood supply of B16F10 melanoma tumors in ND-GFP transgenic mice. Doxorubicin effectively inhibited the formation of these vessels, reducing tumor angiogenesis and growth. This research highlighted the potential of using existing chemotherapy drugs to disrupt tumor blood supply and suggested a novel approach to cancer treatment by targeting hair follicle-derived vascularization.
