In Vivo and In Vitro Evaluation of Hair Growth Potential of Cacumen Platycladi, and GC-MS Analysis of the Active Constituents of Volatile Oil

March 2019 in “ Journal of ethnopharmacology ”

Yan Zhang, Shanshan Chen, Fan-Zhi Qu, Guangyue Su, Yuqing Zhao

Cacumen Platycladi CP extracts dermal papilla cells DPCs C57BL/6 mice volatile oil minoxidil anagen phase GC-MS analysis alopecia CP hair growth hair loss Rogaine

From the encyclopedia

Cacumen Platycladi →

Minoxidil →

An essential vasodilator with some anti-androgenic effects

Studysummary This study found that Cacumen Platycladi volatile oil promotes dermal papilla cell proliferation and enhances hair growth in mice, outperforming minoxidil and showing no obvious cytotoxic effects. Our plain-language summary of this paper — not a Tressless recommendation.

The study evaluated the hair growth potential of Cacumen Platycladi (CP) extracts on dermal papilla cells (DPCs) and C57BL/6 mice. CP volatile oil significantly promoted DPC proliferation by 239.8% compared to control and minoxidil, with no cytotoxicity observed up to 500 μg/mL. In mice, CP volatile oil (0.2 g/kg) accelerated hair growth more effectively than 2% minoxidil, resulting in longer hair and a prolonged anagen phase. GC-MS analysis identified 34 components comprising 81.9% of the total volatile oils. The findings suggested that CP volatile oil could be a potential therapeutic agent for alopecia.

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