In Vivo and In Vitro Evaluation of Hair Growth Potential of Cacumen Platycladi, and GC-MS Analysis of the Active Constituents of Volatile Oil

The study evaluated the hair growth potential of Cacumen Platycladi (CP) extracts on dermal papilla cells (DPCs) and C57BL/6 mice. CP volatile oil significantly promoted DPC proliferation by 239.8% compared to control and minoxidil, with no cytotoxicity observed up to 500 μg/mL. In mice, CP volatile oil (0.2 g/kg) accelerated hair growth more effectively than 2% minoxidil, resulting in longer hair and a prolonged anagen phase. GC-MS analysis identified 34 components comprising 81.9% of the total volatile oils. The findings suggested that CP volatile oil could be a potential therapeutic agent for alopecia.