TLDR Researchers made a cell line that grows quickly and can help with hair growth research.
In the 2010 study, researchers created an immortalized human dermal papilla cell (DPC) line by introducing SV40T and c-myc genes into early-passage human DPCs. These cells preserved key DPC properties and expressed specific markers over 30 passages, with a faster doubling time of 2 days compared to the more than 3.5 days of primary DPCs. The immortalized DPCs showed increased expression of genes related to cell cycle and proliferation. When the conditioned media from these cells were applied to C57/BL6 mice, there was a significant increase in hair weight, indicating a promotion of hair growth. Additionally, the cell line was confirmed to be non-tumorigenic in SCID mice after 12 weeks. The study suggested that the immortalized DPC line is a valuable model for hair growth studies and for identifying new hair growth-promoting compounds.
321 citations,
December 2009 in “Journal of Dermatological Science” Dermal cells are key in controlling hair growth and could potentially be used in hair loss treatments, but more research is needed to improve hair regeneration methods.
13 citations,
June 2007 in “Journal of Dermatological Science” Researchers created a cell line to study hair growth and found specific genes affected by dihydrotestosterone.
277 citations,
June 2003 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” Epithelial-mesenchymal interactions control hair growth cycles through specific molecular signals.
12 citations,
May 2003 in “Journal of dermatological science” Hsc70 protein may influence hair growth by responding to androgens.
190 citations,
October 2002 in “The FASEB journal” Androgens may cause hair loss by increasing TGF-beta1 from scalp cells, which inhibits hair cell growth.
4 citations,
September 2010 in “Journal of Dermatological Science” A new gene location for Keratosis follicularis squamosa was found on chromosome 7p14.3-7p12.1.
October 2024 in “Biology” Dermal papilla cells can help regrow hair and are promising for hair loss treatments.
5 citations,
January 2021 in “iScience” Using a combination of specific cell cycle regulators is better for safely keeping hair root cells alive indefinitely compared to cancer-related methods.
26 citations,
July 2021 in “Frontiers in Cell and Developmental Biology” The review suggests that a special cell-derived treatment shows promise for various skin conditions and hair growth but needs more research for confirmation.
August 2023 in “Research Square (Research Square)” Two microRNAs affect hair follicle development in sheep by targeting specific genes.
