Identification of Androgen-Regulated Genes in SV40-Transformed Human Hair Dermal Papilla Cells

May 2003 in “ Journal of dermatological science ”

Chang Deok Kim, Min Ho Lee, Seok Seon Roh

androgen-regulated genes SV40-transformed human hair dermal papilla cells hair growth regulation cDNA representational difference analysis heat shock cognate protein Hsc70 dihydrotestosterone DHT androgen action hair dermal papilla cells hair growth heat shock protein Hsc70 dihydrotestosterone DHT

TLDR Hsc70 protein may influence hair growth by responding to androgens.

The study investigated androgen-regulated genes in SV40-transformed human hair dermal papilla (DP) cells, which are crucial for hair growth regulation. Using cDNA representational difference analysis, the researchers identified that the heat shock cognate protein, Hsc70, was differentially expressed in response to dihydrotestosterone (DHT) treatment. This suggested that Hsc70 might play a role in androgen action on DP cells.

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Identification of Androgen-Regulated Genes in SV40-Transformed Human Hair Dermal Papilla Cells

Research cited in this study

research Interferon Beta Secreted from Human Hair Dermal Papilla Cells Inhibits the Growth of Outer Root Sheath Cells Cultured in Vitro

research The Biology of Hair Follicles

research Androgen Induction of Follicular Epithelial Cell Growth Is Mediated via Insulin-like Growth Factor-I from Dermal Papilla Cells

research Cultured Dermal Papilla Cells From Androgen-Dependent Human Hair Follicles Contain More Androgen Receptors Than Those From Non-Balding Areas Of Scalp

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