The Medicinal Activity of Lyophilized Aqueous Seed Extract of Lepidium Sativum L. in an Androgenic Alopecia Model

May 2023 in “ Scientific Reports ”

Marzough Aziz Albalawi, Ahmed M. Hafez, Seham S. Elhawary, Nada K. Sedky, Omnia F. Hassan, Rofanda M. Bakeer, Soha Abd El Hadi, Ahmed H. El-Desoky, Sebaey Mahgoub, Fatma A. Mokhtar

Lepidium sativum L. lyophilized seed extract androgenic alopecia 5α-reductase growth factors cholesterol levels 5AR CTGF FGF VEGF minoxidil LSLE AGA 5-alpha-reductase connective tissue growth factor fibroblast growth factor vascular endothelial growth factor Rogaine

From the encyclopedia

Vascular Endothelial Growth Factor →

Minoxidil →

An essential vasodilator with some anti-androgenic effects

Studysummary This study found that Lepidium sativum seed extract showed potential in treating alopecia in rats by reducing 5(alpha)-dihydrotestosterone levels and improving hair length compared to minoxidil.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The research investigated the use of Lepidium sativum L. lyophilized seed extract (LSLE) as a potential treatment for androgenic alopecia (AGA), a common hair loss condition. The study involved 42 male Wistar albino rats with induced AGA. LSLE treatment significantly reduced the activity of the 5α-reductase enzyme, which is linked to hair loss, and increased growth factors and reduced cholesterol levels, both associated with hair growth. LSLE also increased tissue 5AR by 3.16 folds, CTGF to exceed that of the control group, FGF levels by 40%, and VEGF levels by 5 folds compared to the untreated group. LSLE showed the highest hair growth rate compared to the control and minoxidil groups. The study concluded that LSLE has potential as an effective treatment for AGA, with effects comparable to 5% minoxidil.

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