The Medicinal Activity of Lyophilized Aqueous Seed Extract of Lepidium Sativum L. in an Androgenic Alopecia Model

June 2023 in “ Scientific Reports ”

Marzough Aziz Albalawi, Ahmed M. Hafez, Seham S. Elhawary, Nada K. Sedky, Omnia F. Hassan, Rofanda M. Bakeer, Soha Abd El Hadi, Ahmed H. El-Desoky, Sebaey Mahgoub, Fatma A. Mokhtar

Lepidium sativum L. lyophilized seed extract androgenic alopecia 5α-reductase growth factors cholesterol levels 5AR CTGF FGF VEGF minoxidil LSLE AGA 5-alpha-reductase connective tissue growth factor fibroblast growth factor vascular endothelial growth factor Rogaine

TLDR The seed extract of Lepidium sativum L. can potentially treat hair loss, showing effects similar to 5% minoxidil.

The research investigated the use of Lepidium sativum L. lyophilized seed extract (LSLE) as a potential treatment for androgenic alopecia (AGA), a common hair loss condition. The study involved 42 male Wistar albino rats with induced AGA. LSLE treatment significantly reduced the activity of the 5α-reductase enzyme, which is linked to hair loss, and increased growth factors and reduced cholesterol levels, both associated with hair growth. LSLE also increased tissue 5AR by 3.16 folds, CTGF to exceed that of the control group, FGF levels by 40%, and VEGF levels by 5 folds compared to the untreated group. LSLE showed the highest hair growth rate compared to the control and minoxidil groups. The study concluded that LSLE has potential as an effective treatment for AGA, with effects comparable to 5% minoxidil.

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