Effects of Watercress Extract Fraction on R-Spondin 1-Mediated Growth of Human Hair

    Masakazu Hashimoto, Yuka Kawai, Teruaki Masutani, Kiyotaka Tanaka, Kenichi Ito, Arunasiri Iddamalgoda
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    TLDR Watercress extract helps increase hair growth and thickness by blocking hair loss factors.
    The study "Effects of watercress extract fraction on R‐spondin 1‐mediated growth of human hair" investigated the impact of watercress extract (WCE) on hair growth and loss. The research found that WCE significantly increased the secretion of R-spondin 1 (RSPO1), a substance that counteracts the effects of Dickkopf-1 (DKK1), a major hair loss factor. WCE also suppressed the secretion of DKK1, even in the presence of dihydrotestosterone (DHT), a hormone linked to hair loss. In an ex vivo experiment, WCE-treated hair follicles elongated 1.6-fold compared to the control. A 6-month clinical trial showed that a hair lotion containing 2% WCE increased hair thickness and density, improving hair loss symptoms. The study concluded that WCE has strong anti-androgenic effects and potential for treating hair loss.
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