Transepidermal UV Radiation of Scalp Skin Ex Vivo Induces Hair Follicle Damage That Is Alleviated by Topical Treatment with Caffeine

    Jennifer Gherardini, Jeannine Wegner, Jérémy Chéret … Marta Bertolini
    Studysummary This study found that ultraviolet radiation negatively affects hair follicle functions in human scalp skin, and caffeine application may provide some protective effects against this damage.
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    Research cited in this study 35

    1. Efficacy of a Cosmetic Phyto-Caffeine Shampoo in Female Androgenetic Alopecia Giornale italiano di dermatologia e venereologia · 2020
    2. Nuclear Factor (Erythroid-Derived 2)-Like-2 Pathway Modulates Substance P–Induced Human Mast Cell Activation and Degranulation in the Hair Follicle The Journal of Allergy and Clinical Immunology · 2018
    3. Review of Human Hair Optical Properties in Possible Relation to Melanoma Development Journal of Biomedical Optics · 2018
    4. Establishment of an Evaluation Method to Detect Drug Distribution in Hair Follicles International Journal of Pharmaceutics · 2018
    5. Development of a Stiffness-Angle Law for Simplifying the Measurement of Human Hair Stiffness International Journal of Cosmetic Science · 2018
    6. Topically Applied Nicotinamide Inhibits Human Hair Follicle Growth Ex Vivo ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2017
    7. Low-Level Laser Therapy for the Treatment of Androgenic Alopecia: A Review Lasers in Medical Science · 2017
    8. A Review of Monochromatic Light Devices for the Treatment of Alopecia Areata Lasers in Medical Science · 2017
    9. UVA-1 in the Treatment of Alopecia Areata Dermatologic therapy · 2017
    10. Characterization of Cell Cycle Arrest and Terminal Differentiation in a Maximally Proliferative Human Epithelial Tissue: Lessons from the Human Hair Follicle Matrix European Journal of Cell Biology · 2017
    11. An Open-Label Randomized Multicenter Study Assessing the Noninferiority of a Caffeine-Based Topical Liquid 0.2% Versus Minoxidil 5% Solution in Male Androgenetic Alopecia Skin Pharmacology and Physiology · 2017
    12. The Role of Tight Junctions in Skin Barrier Function and Dermal Absorption Journal of controlled release · 2016
    13. The Thyroid Hormone Analogue KB2115 (Eprotirome) Prolongs Human Hair Growth (Anagen) Ex Vivo Journal of Investigative Dermatology · 2016
    14. Sebaceous Lipids Are Essential for Water Repulsion, Protection Against UVB-Induced Apoptosis, and Ocular Integrity in Mice Development · 2016
    15. The Impact of Oxidative Stress on Hair International Journal of Cosmetic Science · 2015
    16. A Guide to Studying Human Hair Follicle Cycling In Vivo Journal of Investigative Dermatology · 2015
    17. Human Hair Follicle Organ Culture: Theory, Application, and Perspectives Experimental Dermatology · 2015
    18. Effect of Ultraviolet Radiation, Smoking, and Nutrition on Hair Current problems in dermatology · 2015
    19. Identification of Ultraviolet B Radiation-Induced MicroRNAs in Normal Human Dermal Papilla Cells Molecular Medicine Reports · 2014
    20. Differential Effects of Caffeine on Hair Shaft Elongation, Matrix and Outer Root Sheath Keratinocyte Proliferation, and Transforming Growth Factor-β2/Insulin-Like Growth Factor-1-Mediated Regulation of the Hair Cycle in Male and Female Human Hair Follicles In Vitro British Journal of Dermatology · 2014
    21. Lichen Planopilaris Is Characterized By Immune Privilege Collapse Of The Hair Follicle's Epithelial Stem Cell Niche The Journal of Pathology · 2013
    22. Caffeine’s Mechanisms of Action and Its Cosmetic Use Skin Pharmacology and Physiology · 2012
    23. Ultraviolet B Preconditioning Enhances the Hair Growth-Promoting Effects of Adipose-Derived Stem Cells Via Generation of Reactive Oxygen Species Stem Cells and Development · 2012
    24. A Novel Cosmetic Approach to Treat Thinning Hair British Journal of Dermatology · 2011
    25. Thyroid-Stimulating Hormone: A Novel, Locally Produced Modulator of Human Epidermal Functions, Regulated by Thyrotropin-Releasing Hormone and Thyroid Hormones Endocrinology · 2010
    26. Permeation of Topically Applied Caffeine Through Human Skin – A Comparison of In Vivo and In Vitro Data BJCP. British journal of clinical pharmacology/British journal of clinical pharmacology · 2009
    27. Profiling the Response of Human Hair Follicles to Ultraviolet Radiation Journal of Investigative Dermatology · 2009
    28. The Role of Hair Follicles in the Percutaneous Absorption of Caffeine BJCP. British journal of clinical pharmacology/British journal of clinical pharmacology · 2007
    29. Probing the Effects of Stress Mediators on the Human Hair Follicle American Journal of Pathology · 2007
    30. Dissecting the Impact of Chemotherapy on the Human Hair Follicle ˜The œAmerican journal of pathology · 2007
    31. Follicular Penetration of Topically Applied Caffeine via a Shampoo Formulation Skin Pharmacology and Physiology · 2007
    32. Effect of Caffeine and Testosterone on the Proliferation of Human Hair Follicles In Vitro International Journal of Dermatology · 2007
    33. Psychological Effect, Pathophysiology, and Management of Androgenetic Alopecia in Men Mayo Clinic Proceedings · 2005
    34. Caffeine Ameliorates Radiation-Induced Skin Reactions in Mice but Does Not Influence Tumor Radiation Response Journal of Radiological Protection · 2002
    35. Overexpression of Bcl-2 Protects from Ultraviolet B-Induced Apoptosis but Promotes Hair Follicle Regression and Chemotherapy-Induced Alopecia ˜The œAmerican journal of pathology · 2000