Distinctive Histopathologic Findings in Linear Morphea (En Coup De Sabre) Alopecia

    March 2013 in “ Journal of Cutaneous Pathology ”
    Margareth Pierre-Louis, Leonard C. Sperling, Mark S. Wilke, Maria Hordinsky
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    TLDR The study found unique skin changes in a rare type of alopecia linked to a skin condition called linear morphea.
    In 2013, researchers studied a 26-year-old Caucasian female with linear morphea en coup de sabre, which is associated with alopecia and facial/scalp depression. A scalp biopsy showed unique histopathologic features: dense dermal sclerosis, significant eccrine gland atrophy, absence of sebaceous glands, and atrophic follicular remnants different from typical telogen follicles, suggesting permanent alopecia. This type of alopecia had not been previously reported in morphea or other cicatricial alopecias. The study compared these findings to permanent alopecia caused by chemotherapy, noting histopathologic similarities. The case emphasized the role of histopathology in diagnosing alopecia and implied that early aggressive treatment might prevent the permanent changes seen in the follicular remnants.
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