TLDR Tight junctions are key for skin protection and controlling what gets absorbed or passes through the skin.
The document from 2016 discusses the skin's role in protecting the body from external threats and preventing water and solute loss, highlighting the importance of the skin's complex barrier system, which includes the stratum corneum, tight junctions, the microbiome, chemical, and immunological barriers. These barriers are interconnected and can influence each other, particularly in response to external manipulation or skin diseases. The focus is on the mechanical barriers, the stratum corneum and tight junctions, which are crucial for drug delivery and skin absorption. Tight junctions, located in the stratum granulosum and the companion cell layer of hair follicles, are emphasized for their central role and rapid response to stimuli. The document summarizes current knowledge on tight junction function in the epidermis and hair follicles, their interaction with other skin barrier components, and their significance in health, disease, and drug delivery, including examples of tight junction modulators.
43 citations,
July 2016 in “European journal of pharmaceutical sciences” Scientists created tiny particles that release medicine on the skin and in hair, working better at certain pH levels and being safe for skin cells.
21 citations,
December 2015 in “European journal of cell biology” Tight junctions create a barrier in pig hair follicles that controls what can enter the skin.
97 citations,
September 2011 in “British Journal of Dermatology” The human hair follicle can store topical compounds and be targeted for drug delivery with minimal side effects.
63 citations,
April 2005 in “Mechanisms of development” Mice with too much Claudin-6 have skin barrier problems and abnormal hair growth.
39 citations,
August 2018 in “Scientific reports” Claudin-1 is important for the barrier function and growth of hair.
November 2023 in “Linköping University medical dissertations” Keratinocytes and adipose-derived stem cells can effectively heal difficult skin wounds.
1 citations,
January 2019 in “Elsevier eBooks” Electrospun matrices help regenerate skin and hair follicles using PCL and collagen scaffolds.
59 citations,
June 2008 in “Journal of The American Academy of Dermatology” The article explains the genetic causes and symptoms of various hair disorders and highlights the need for more research to find treatments.
9 citations,
September 2013 in “Journal of histochemistry and cytochemistry/The journal of histochemistry and cytochemistry” Matriptase is highly active in hair follicles and sebaceous glands, especially during hair growth phases.
