TLDR Mice with too much Claudin-6 have skin barrier problems and abnormal hair growth.
The study on Inv-Cldn6 mice, which overexpressed Claudin-6, demonstrated delayed epidermal permeability barrier (EPB) formation and various hair follicle abnormalities. These mice initially experienced dehydration due to an incomplete EPB but normalized by postnatal day 12. They exhibited a distinct coat phenotype, mild epidermal hyperkeratosis, and altered expression of keratins and claudins. Hair follicle differentiation was disrupted, with a shorter anagen phase and changes in hair type distribution, including a 20% increase in zig-zag hairs and 30% shorter guard hairs. The findings suggested that Claudin-6 played a crucial role in epidermal and hair follicle differentiation, highlighting its importance in EPB assembly and the hair cycle.
155 citations
,
August 2003 in “Journal Of Experimental Zoology Part B: Molecular And Developmental Evolution” Understanding hair growth involves complex interactions between molecules and could help treat hair disorders.
425 citations
,
August 2002 in “BioEssays” The cornified cell envelope forms a protective barrier in skin and hair, using specific proteins and lipids to maintain effectiveness.
86 citations
,
December 2001 in “Experimental dermatology” Mutant mice help researchers understand hair growth and related genetic factors.
238 citations
,
October 1994 in “Current opinion in genetics & development” The document concludes that recent research has improved understanding of skin diseases and the balance between cell growth and differentiation in the epidermis.
356 citations
,
December 1986 in “The journal of cell biology/The Journal of cell biology” Hair and nail cells share similar proteins, indicating a common differentiation pathway.
521 citations
,
January 1954 in “Physiological Reviews” Hair growth is cyclic and influenced mainly by local factors.
156 citations
,
August 2016 in “Journal of controlled release” Tight junctions are key for skin protection and controlling what gets absorbed or passes through the skin.
23 citations
,
February 2015 in “The American journal of pathology” Keratosis pilaris is often linked to genetic mutations and causes skin and hair abnormalities, regardless of those mutations.
61 citations
,
January 2011 in “PloS one” Notch signaling is essential for healthy skin and hair follicle maintenance.
2 citations
,
December 2023 in “International journal of molecular sciences” Understanding keratinization is crucial for treating skin conditions like ichthyoses and psoriasis.
39 citations
,
November 2005 in “The journal of investigative dermatology/Journal of investigative dermatology” Fatp4 is crucial for healthy skin development and function.
