TLDR Understanding keratinization is crucial for treating skin conditions like ichthyoses and psoriasis.
The document discusses the complex process of skin keratinization, emphasizing the roles of various proteins, such as keratins and filaggrin, in maintaining skin barrier function and integrity. It highlights the significance of calcium gradients, pH levels, and intercellular junctions in keratinocyte differentiation and barrier formation. Disruptions in these processes, often due to genetic mutations or immune-related pathologies, can lead to skin conditions like ichthyoses, psoriasis, and epidermolytic hyperkeratosis. Understanding these mechanisms is crucial for developing targeted treatments for these dermatological diseases.
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