Key Factors in the Complex and Coordinated Network of Skin Keratinization: Their Significance and Involvement in Common Skin Conditions

December 2023 in “ International journal of molecular sciences ”

Nives Pondeljak, Liborija Lugović‐Mihić, Lucija Tomić, Ena Parać, Lovre Pedić, Elvira Lazić Mosler

keratinization desquamation keratinocyte differentiation growth factors interleukins vitamin A Ca2+ concentration protein expression pH gradients ichthyoses psoriasis keratin proteins calcium concentration keratin

TLDR Understanding keratinization is crucial for treating skin conditions like ichthyoses and psoriasis.

The document discusses the complex process of skin keratinization, emphasizing the roles of various proteins, such as keratins and filaggrin, in maintaining skin barrier function and integrity. It highlights the significance of calcium gradients, pH levels, and intercellular junctions in keratinocyte differentiation and barrier formation. Disruptions in these processes, often due to genetic mutations or immune-related pathologies, can lead to skin conditions like ichthyoses, psoriasis, and epidermolytic hyperkeratosis. Understanding these mechanisms is crucial for developing targeted treatments for these dermatological diseases.

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Key Factors in the Complex and Coordinated Network of Skin Keratinization: Their Significance and Involvement in Common Skin Conditions

Research cited in this study

research Keratosis Pilaris

research Ichthyosis Follicularis With Alopecia And Photophobia Syndrome With Coexisting Palmoplantar Keratoderma Treated With Acitretin

research Modulating the Stem Cell Niche for Tissue Regeneration

research The Expanding Significance of Keratin Intermediate Filaments in Normal and Diseased Epithelia

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research Epidermal Notch Signaling: Differentiation, Cancer, and Adhesion

research Sic Transit Gloria: Farewell to the Epidermal Transit Amplifying Cell?

research Epithelial Stem Cells: Turning Over New Leaves

research Hard and Soft Principles Defining the Structure, Function, and Regulation of Keratin Intermediate Filaments

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