TLDR Understanding keratinization is crucial for treating skin conditions like ichthyoses and psoriasis.
The document discusses the complex process of skin keratinization, emphasizing the roles of various proteins, such as keratins and filaggrin, in maintaining skin barrier function and integrity. It highlights the significance of calcium gradients, pH levels, and intercellular junctions in keratinocyte differentiation and barrier formation. Disruptions in these processes, often due to genetic mutations or immune-related pathologies, can lead to skin conditions like ichthyoses, psoriasis, and epidermolytic hyperkeratosis. Understanding these mechanisms is crucial for developing targeted treatments for these dermatological diseases.
Cited in this study
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1 citations
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March 2023 in “Tidsskrift for Den norske lægeforening” Keratosis pilaris is a common skin condition causing a bumpy texture, sometimes linked to other diseases, with various treatments available.
1 citations
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January 2022 in “International journal of trichology” A girl with a rare skin condition improved after one month of treatment with acitretin.
480 citations
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August 2014 in “Nature Biotechnology” Changing the environment around stem cells could help tissue repair, but it's hard to be precise and avoid side effects.
186 citations
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February 2013 in “Current opinion in cell biology” Keratin proteins are increasingly recognized as important for cell health and are linked to many diseases.
253 citations
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April 2008 in “Current opinion in cell biology” Notch signalling helps skin cells differentiate and prevents tumors.
153 citations
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October 2007 in “Cell Stem Cell” New research suggests that skin cell renewal may not require a special type of cell previously thought to be essential.
508 citations
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February 2007 in “Cell” Epithelial stem cells are crucial for tissue renewal and repair, and understanding them could improve treatments for damage and cancer.
