Key Factors in the Complex and Coordinated Network of Skin Keratinization: Their Significance and Involvement in Common Skin Conditions

December 2023 in “ International journal of molecular sciences ”

Nives Pondeljak, Liborija Lugović‐Mihić, Lucija Tomić, Ena Parać, Lovre Pedić, Elvira Lazić Mosler

keratinization desquamation keratinocyte differentiation growth factors interleukins vitamin A Ca2+ concentration protein expression pH gradients ichthyoses psoriasis keratin proteins calcium concentration keratin

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Studysummary This study reviews the complex keratinization process in the epidermis, detailing how various factors regulate keratinocyte differentiation and emphasizing the importance of understanding this process for the pathogenesis of skin disorders like ichthyoses and psoriasis.

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