Transcriptome Meta-Analysis Confirms the Hidradenitis Suppurativa Pathogenic Triad: Upregulated Inflammation, Altered Epithelial Organization, and Dysregulated Metabolic Signaling

    September 2022 in “ Biomolecules ”
    Ana Sofia Lima Estevão de Oliveira, Giovanna Bloise, Chiara Moltrasio … Lucas André Cavalcanti Brandão
    Studysummary This study found that specific gene upregulations and mutations in hidradenitis suppurativa skin support the role of inflammation, altered epithelial differentiation, and metabolism dysregulation in the disease's pathogenesis.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 7

    1. Hidradenitis Suppurativa and Comorbid Disorder Biomarkers, Druggable Genes, New Drugs and Drug Repurposing—A Molecular Meta-Analysis Pharmaceutics · 2021
    2. Histologic Progression of Acne Inversa/Hidradenitis Suppurativa: Implications for Future Investigations and Therapeutic Intervention Experimental dermatology · 2021
    3. Adipokines in the Skin and Dermatological Diseases International journal of molecular sciences · 2020
    4. What Causes Hidradenitis Suppurativa?—15 Years After Experimental Dermatology · 2020
    5. Matrix Remodelling and MMP Expression/Activation Are Associated with Hidradenitis Suppurativa Skin Inflammation Experimental Dermatology · 2019
    6. Impaired Notch-MKP-1 Signalling in Hidradenitis Suppurativa: An Approach to Pathogenesis by Evidence from Translational Biology Experimental dermatology · 2013
    7. Identification of Stem Cell Populations in Sweat Glands and Ducts Reveals Roles in Homeostasis and Wound Repair Cell · 2012