Transcriptome Meta-Analysis Confirms the Hidradenitis Suppurativa Pathogenic Triad: Upregulated Inflammation, Altered Epithelial Organization, and Dysregulated Metabolic Signaling
September 2022
in “
Biomolecules
”
hidradenitis suppurativa inflammation epithelial organization metabolic signaling keratinocytes hyperkeratosis immune cell infiltration follicular occlusion nodule formation cytokines TNF-α IL-1β IFN-γ B cells plasma cells gene expression immune responses extracellular matrix organization metabolic pathways HS tumor necrosis factor alpha interleukin-1 beta interferon gamma
TLDR The research confirms that Hidradenitis Suppurativa is characterized by increased inflammation, disrupted skin cell organization, and abnormal metabolic processes.
The meta-analysis of transcriptome data in hidradenitis suppurativa (HS) confirms a pathogenic triad involving upregulated inflammation, altered epithelial organization, and dysregulated metabolic signaling. Key findings include abnormal inflammatory profiles in keratinocytes, leading to hyperkeratosis and immune cell infiltration, follicular occlusion, and nodule formation. The study highlights the role of cytokines such as TNF-α, IL-1β, and IFN-γ in driving inflammation, and identifies potential therapeutic targets, including B cells and plasma cells. The analysis also reveals significant gene expression changes related to immune responses, extracellular matrix organization, and metabolic pathways, providing a comprehensive understanding of HS pathogenesis.
