Histologic Progression of Acne Inversa/Hidradenitis Suppurativa: Implications for Future Investigations and Therapeutic Intervention

January 2021 in “ Experimental dermatology ”

Robert W. Dunstan, K. Salte, Viktor Todorović, Margaret M. Lowe, J. Wetter, Paul W. Harms, Richard E. Burney, Victoria E. Scott, Kathleen M. Smith, Michael D. Rosenblum, Jóhann E. Guðjónsson, Prisca Honoré

acne inversa hidradenitis suppurativa hair follicles cysts epithelial tendrils stem cell markers inflammation cyst rupture immunohistochemistry hematoxylin and eosin staining AI HS

Studysummary This study found that acne inversa is primarily an epithelial-driven disease, with cyst-forming tendrils causing inflammation due to rupture and the release of debris, highlighting limitations of punch biopsies for analysis.

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