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research Mutations in γ-secretase subunit–encoding PSENEN underlie Dowling-Degos disease associated with acne inversa

87 citations , March 2017 in “Journal of Clinical Investigation”

In this study, researchers identified PSENEN mutations that can lead to a form of Dowling-Degos disease, characterized by follicular hyperkeratosis and an increased susceptibility to acne inversa, especially in the presence of certain trigger factors.

T Helper 17 Cell/Regulatory T-Cell Imbalance in Hidradenitis Suppurativa/Acne Inversa: The Link to Hair Follicle Dissection, Obesity, Smoking, and Autoimmune Comorbidities

research T helper 17 cell/regulatory T-cell imbalance in hidradenitis suppurativa/acne inversa: the link to hair follicle dissection, obesity, smoking and autoimmune comorbidities

66 citations , March 2018 in “British journal of dermatology/British journal of dermatology, Supplement”

This article reviews the role of perifollicular regulatory T cells in maintaining hair follicle integrity in the context of hidradenitis suppurativa and calls attention to inflammatory mechanisms without reporting new clinical results.

research Swiss Practice Recommendations for the Management of Hidradenitis Suppurativa/Acne Inversa

52 citations , January 2017 in “Dermatology”

This article provides diagnostic and therapeutic recommendations for hidradenitis suppurativa based on a systematic literature search and expert consensus, but reports no new clinical results.

research S2k guideline for the treatment of hidradenitis suppurativa / acne inversa – Short version

41 citations , May 2024 in “JDDG Journal der Deutschen Dermatologischen Gesellschaft”

This guideline outlines therapies for hidradenitis suppurativa/acne inversa, noting that oral tetracyclines, clindamycin, and surgical options are important for treatment, with adalimumab, secukinumab, and bimekizumab also approved.

research Hidradenitis suppurativa/Acne inversa: an endocrine skin disorder?

41 citations , June 2016 in “Reviews in endocrine and metabolic disorders”

This review discusses the role of hormonal dysregulation and metabolic syndrome in hidradenitis suppurativa and reports no new clinical results.

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community Starting minoxidil and looking for a few tips

8 upvotes 8 months ago

The conversation is about using minoxidil for diffuse thinning after finasteride showed no regrowth. Tips include applying minoxidil directly to the scalp, considering potential shedding, and being cautious with combining tretinoin due to possible irritation.

community Increased adipose tissue (being overweight) in males may increase likelyhood of finasterde side effects

in Research/Science 29 upvotes 2 years ago

Being overweight may increase finasteride side effects due to higher aromatase activity converting testosterone to estradiol. Maintaining a healthy weight could reduce these side effects.

community Shedding kind of looks like balding

in Progress Pictures 11 upvotes 1 month ago

The conversation discusses hair loss treatments, primarily finasteride, and the effects of shedding, miniaturization, and regrowth. Users share experiences with finasteride, minoxidil, and dutasteride, noting normal shedding patterns and potential regrowth signs like baby hairs.

community So we have 20k dollars human like machines available but no new effective treatment for hairloss since finasteride :)

in Chat 237 upvotes 1 year ago

There have been no new effective hair loss treatments since finasteride, despite technological advancements. Current treatments include finasteride, minoxidil, and RU58841, with ongoing challenges and potential future solutions in research.

community My friend is so terrified of balding, he started microdosing estrogen…

in Treatment 1522 upvotes 9 months ago

A person is microdosing estrogen for hair loss after finasteride and dutasteride failed, risking feminizing effects. Alternatives like minoxidil, RU58841, or hair transplants are suggested.

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