Keratin 17 in Disease Pathogenesis: From Cancer to Dermatoses

    October 2018 in “ Journal of pathology ”
    Luting Yang, Shaolong Zhang, Gang Wang
    Studysummary This review discusses the mechanisms of keratin 17 regulation in diseases such as psoriasis and cancers but presents no new experimental findings, calling for further exploration of anti-K17 therapies.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 9

    1. Types I and II Keratin Intermediate Filaments Cold Spring Harbor Perspectives in Biology · 2018
    2. p53 Is a Direct Transcriptional Repressor of Keratin 17: Lessons from a Rat Model of Radiation Dermatitis Journal of Investigative Dermatology · 2015
    3. Homozygous Dominant Missense Mutation in Keratin 17 Leads to Alopecia in Addition to Severe Pachyonychia Congenita Journal of Investigative Dermatology · 2012
    4. Type I Keratin 17 Protein Is Phosphorylated on Serine 44 by p90 Ribosomal Protein S6 Kinase 1 in a Growth- and Stress-Dependent Fashion Journal of biological chemistry/˜The œJournal of biological chemistry · 2011
    5. Keratin 17 Modulates Hair Follicle Cycling in a TNFα-Dependent Fashion Genes & Development · 2006
    6. Exploiting the Keratin 17 Gene Promoter to Visualize Live Cells in Epithelial Appendages of Mice Molecular and Cellular Biology · 2005
    7. Keratin 17 Null Mice Exhibit Age- And Strain-Dependent Alopecia Genes & Development · 2002
    8. Keratin 17 Mutations Cause Either Steatocystoma Multiplex or Pachyonychia Congenita Type 2 British Journal of Dermatology · 1998
    9. Keratin 17 Gene Expression During the Murine Hair Cycle Journal of Investigative Dermatology · 1997