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GlossaryKeratin 17 (K17)

protein crucial for skin, hair, and nail structure

Keratin 17 (K17) is a type of protein found in the skin, hair follicles, and nails, playing a crucial role in their structural integrity and resilience. It is also involved in cellular processes like growth and repair, and its abnormal expression is linked to certain skin disorders and cancers.

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research The Expanding Significance of Keratin Intermediate Filaments in Normal and Diseased Epithelia

186 citations, December 2012 in “Current opinion in cell biology”

Keratin proteins are increasingly recognized as important for cell health and are linked to many diseases.

research A Novel Human Type II Cytokeratin, K6hf, Specifically Expressed in the Companion Layer of the Hair Follicle

139 citations, December 1998 in “The journal of investigative dermatology/Journal of investigative dermatology”

K6hf is a unique protein found only in a specific layer of hair follicles.

research Keratin 17 in Disease Pathogenesis: From Cancer to Dermatoses

62 citations, October 2018 in “Journal of pathology”

Keratin 17 is linked to various diseases, including cancer and skin conditions, and may be a target for diagnosis and treatment.

research Type I Keratin 17 Protein Is Phosphorylated on Serine 44 by p90 Ribosomal Protein S6 Kinase 1 in a Growth- and Stress-Dependent Fashion

30 citations, December 2011 in “Journal of biological chemistry/The Journal of biological chemistry”

Keratin 17 is modified by RSK1 in response to growth and stress, affecting skin growth and stress response.

research Development, Structure, and Keratin Expression in C57BL/6J Mouse Eccrine Glands

29 citations, November 2011 in “Veterinary pathology”

The study found that mouse sweat glands develop before birth, mature after birth, and have specific keratin patterns.

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