research Clinicopathological Features and Expression of Four Keratins (K10, K14, K17, and K19) in Six Cases of Eruptive Vellus Hair Cysts
Eruptive vellus hair cysts likely originate from the infrainfundibulum and sebaceous duct.
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5 / 249 resultsresearch A Novel Mouse Type I Intermediate Filament Gene, Keratin 17n (K17n), Exhibits Preferred Expression in Nail Tissue
The study identified a novel mouse gene, Keratin 17n (K17n), which was predominantly expressed in nail tissue and likely compensated for the absence of Keratin 17 (K17) in mK17 null mice, explaining the lack of nail abnormalities despite hair loss. The gene was located near mK17 on mouse chromosome 11 and shared significant homology, suggesting a common origin. The findings implied that a human equivalent might exist, potentially clarifying phenotypic variability in K17-related diseases like pachyonychia congenita. The research involved sequencing and characterizing the mK17n gene using molecular biology techniques, contributing to the understanding of keratin gene expression and its implications in keratin-based diseases.
research The Expanding Significance of Keratin Intermediate Filaments in Normal and Diseased Epithelia
Keratin proteins are increasingly recognized as important for cell health and are linked to many diseases.
research Keratin 17 modulates hair follicle cycling in a TNFα-dependent fashion
Keratin 17 is crucial for normal hair growth by regulating hair cycle transitions with TNFα.
research A Novel Human Type II Cytokeratin, K6hf, Specifically Expressed in the Companion Layer of the Hair Follicle
K6hf is a unique protein found only in a specific layer of hair follicles.
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