A Novel Mouse Type I Intermediate Filament Gene, Keratin 17n, Exhibits Preferred Expression in Nail Tissue

The study identified a novel mouse gene, Keratin 17n (K17n), which was predominantly expressed in nail tissue and likely compensated for the absence of Keratin 17 (K17) in mK17 null mice, explaining the lack of nail abnormalities despite hair loss. The gene was located near mK17 on mouse chromosome 11 and shared significant homology, suggesting a common origin. The findings implied that a human equivalent might exist, potentially clarifying phenotypic variability in K17-related diseases like pachyonychia congenita. The research involved sequencing and characterizing the mK17n gene using molecular biology techniques, contributing to the understanding of keratin gene expression and its implications in keratin-based diseases.