Keratin Expression in the Normal Nail Unit: Markers of Regional Differentiation

    January 2000 in “ British Journal of Dermatology ”
    D. de Berker, Fenella Wojnarowska, Lisbet Sviland, Gillian E. Westgate, R.P.R. DAWBER, Irene M. Leigh
    TLDR Different parts of the nail express different keratins, showing unique patterns of differentiation.
    The study examined keratin expression in the nail unit using antikeratin monoclonal antibodies, revealing distinct patterns of differentiation. The nail matrix uniquely expressed the acidic hair-type keratin Ha1, alongside epidermal keratins K1 and K10, with occasional K17 at the matrix apex. K6 and K16 were present at the ventral aspect of the proximal nail fold. The nail bed lacked Ha1 and markers of cornified and mucosal differentiation but contained K6, K16, and K17, indicating minimal differentiation due to the nail's properties. In the digit pulp, K6, K16, and K17 were found in limited amounts, possibly linked to the eccrine duct's epidermal component. Simple epithelial keratins K7, K8, and K18 were present in younger individuals, mainly in epibasal cells and putative Merkel cells.
    Discuss this study in the Community →

    Research cited in this study

    11 / 11 results

    Related Community Posts Join

    6 / 166 results

      community Reminder: Biotin supplementation is a scam.

      in Product  113 upvotes 2 years ago
      Biotin supplements are considered ineffective for hair loss and are not supported by evidence. People in the conversation have mixed experiences, with some noting benefits for nails and skin but not hair, while others continue to use biotin as part of their vitamin regimen.

      community Keratin fibers vs. Gossypium Herbaceum Hair fibers

      in Product  1 upvotes 1 year ago
      The conversation is about comparing keratin hair fibers to Gossypium Herbaceum hair fibers for diffuse hair loss. The user prefers keratin fibers for their durability and is seeking a bulk purchase option.

      community Keratin microspheres - breakthrough

      in Research/Science  13 upvotes 1 year ago
      A gel of keratin microspheres promotes hair follicle growth, showing similar effectiveness to minoxidil in mice. The treatment activates hair growth pathways and reduces inflammation, with potential applications in drug delivery for hair-related disorders.

      community Discussion: Keratin Microsphere Results

      in Treatment  29 upvotes 1 year ago
      Keratin microspheres may offer additional mechanisms to combat hair loss compared to minoxidil. The process to create these microspheres is relatively simple and can be done at home with basic equipment.

      community Let's talk keratin products and hair loss

      in Styling  2 upvotes 3 months ago
      OP is considering using a keratin gel to improve hair quality and is concerned about its safety and visual impact on a slightly balding crown. Users discuss shampoo frequency, with some suggesting less frequent use for better hair health, but OP prefers regular shampoo and conditioner for silky hair.

    Related Research

    5 / 5 results