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    Glossary Keratin 6

    protein in skin, hair, and nails providing structural support

    Keratin 6 (K6) is a type of protein found in the epithelial cells of the skin, hair, and nails. It plays a crucial role in the structural integrity and resilience of these tissues. Mutations in the KRT6 gene, which encodes Keratin 6, can lead to disorders such as pachyonychia congenita, characterized by thickened nails and other skin abnormalities.

    Related Terms

    Learn 3 of 6

    1. Keratin
    2. Hydrolyzed Keratin
    3. Alpha Keratin
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    Research 10 of 1000+

    1. Interleukin-1 Induces Transcription of Keratin K6 in Human Epidermal Keratinocytes 2001 · 90 citations
    2. A novel control of human keratin expression: cannabinoid receptor 1-mediated signaling down-regulates the expression of keratins K6 and K16 in human keratinocytes<i>in vitro</i>and<i>in situ</i> PeerJ · 2013 · 66 citations
    3. Keratin K6irs is specific to the inner root sheath of hair follicles in mice and humans British Journal of Dermatology · 2001 · 38 citations
    4. K6irs1, K6irs2, K6irs3, and K6irs4 Represent the Inner-Root-Sheath-Specific Type II Epithelial Keratins of the Human Hair Follicle1 Journal of Investigative Dermatology · 2003 · 130 citations
    5. Type II Epithelial Keratin 6hf (K6hf) Is Expressed in the Companion Layer, Matrix, and Medulla in Anagen-Stage Hair Follicles Journal of Investigative Dermatology · 2003 · 60 citations
    6. Expression of keratins K6 and K16 in regenerating mouse epidermis is less restricted by cell replication than the expression of K1 and K10. PubMed · 1994 · 13 citations
    7. Discovery of a novel murine keratin 6 (K6) isoform explains the absence of hair and nail defects in mice deficient for K6a and K6b The Journal of Cell Biology · 2001 · 101 citations
    8. Expression of Keratin 75 (K6hf) in Oral Squamous Cell Carcinoma Dental Medicine Research · 2011 · 2 citations
    9. Peer Review #2 of "A novel control of human keratin expression: cannabinoid receptor 1-mediated signaling down-regulates the expression of keratins K6 and K16 in human keratinocytes in vitro and in situ (v0.1)" 2013
    10. Peer Review #1 of "A novel control of human keratin expression: cannabinoid receptor 1-mediated signaling down-regulates the expression of keratins K6 and K16 in human keratinocytes in vitro and in situ (v0.1)" 2013
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    Community 10 of 40

    1. Seeking Supplement Advice for Keratin Enhancement and Hair Flattening Community · 16 Feb 2026
    2. Let's talk keratin products and hair loss Reddit · 22 Sept 2025
    3. My brain absorbing the assorted off label drugs I put near it on a daily basis just for maximum keratin production Reddit · 29 Nov 2024
    4. Keratin fibers vs. Gossypium Herbaceum Hair fibers Reddit · 31 Aug 2024
    5. Is Biotin or Keratin shampoo better for hair health/growth Reddit · 4 May 2024
    6. Question about seborrheic dermatitis and keratin Reddit · 16 May 2019
    7. Apparently, Keratin Microsphere products are already on the market. Gonna give it a college try, wish me luck! Reddit · 20 Sept 2024
    8. Is it safe to get keratin treatment on transplanted hair? Reddit · 10 Aug 2024
    9. Male - 25 y.o - gulfs slowly fading like my father’s - topical minoxidil, soon starting fin + keratine supplement Community · 15 Jul 2024
    10. Keratin microspheres - breakthrough Reddit · 6 Mar 2024
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