Keratin 17 Null Mice Exhibit Age- And Strain-Dependent Alopecia

June 2002 in “ Genes & Development ”

Kevin McGowan, Xuemei Tong, Emma Colucci‐Guyon, Francina Langa, Charles Babinet, Pierre A. Coulombe

Keratin 17 K17 alopecia hair fragility follicular histology apoptosis matrix cells keratins K16 pachyonychia congenita steatocystoma multiplex

Studysummary This study found that K17 is crucial for the structural integrity and survival of hair-producing cells, with K17 null mice developing alopecia due to hair fragility and follicular alterations.

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