The Functional Diversity of Epidermal Keratins Revealed by the Partial Rescue of the Keratin 14 Null Phenotype by Keratin 16

    September 1999 in “ ˜The œjournal of cell biology/˜The œJournal of cell biology ”
    Rudolph D. Paladini, Pierre A. Coulombe
    Studysummary In this study, expressing human K16 in the epidermis of K14 null mice prevented early skin blistering but led to age-related anomalies, indicating K16 and K14 have distinct roles despite their sequence similarity.
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    Research cited in this study 11

    1. Keratin 15 Expression in Stratified Epithelia: Downregulation in Activated Keratinocytes Journal of Investigative Dermatology · 1999
    2. CDNA Cloning, Expression, And Assembly Characteristics Of Mouse Keratin 16 Journal of Biological Chemistry · 1998
    3. Onset of Keratin 17 Expression Coincides with the Definition of Major Epithelial Lineages During Skin Development The Journal of Cell Biology · 1998
    4. The Two Functional Keratin 6 Genes of Mouse Are Differentially Regulated and Evolved Independently from Their Human Orthologs Genomics · 1998
    5. Directed Expression of Keratin 16 to the Progenitor Basal Cells of Transgenic Mouse Skin Delays Skin Maturation The Journal of Cell Biology · 1998
    6. Defining a Region of the Human Keratin 6a Gene That Confers Inducible Expression in Stratified Epithelia of Transgenic Mice Journal of Biological Chemistry · 1997
    7. Keratin 19 as a Biochemical Marker of Skin Stem Cells In Vivo and In Vitro: Localization and Variation with Age and Culture Stage Journal of Cell Science · 1996
    8. Overexpression of Human Keratin 16 Produces a Distinct Skin Phenotype in Transgenic Mouse Skin Biochemistry and Cell Biology · 1995
    9. Mutation of a Type II Keratin Gene (K6a) in Pachyonychia Congenita Nature Genetics · 1995
    10. Increased Expression of Keratin 16 Causes Anomalies in Cytoarchitecture and Keratinization in Transgenic Mouse Skin The Journal of Cell Biology · 1994
    11. Three cDNA Sequences of Mouse Type I Keratins: Cellular Localization of the mRNAs in Normal and Hyperproliferative Tissues Journal of Biological Chemistry · 1987

    Related research 1

    1. Keratin and Skin Disorders Cell biology international · 1996