CDNA Cloning, Expression, And Assembly Characteristics Of Mouse Keratin 16

November 1998 in “ Journal of Biological Chemistry ”

Rebecca M. Porter, A. M. Hutcheson, E.L. Rugg, Roy A. Quinlan, E. Birgitte Lane

keratin 16 K16 helical domain filament assembly K8/K18 network tail domain

Studysummary This study found that the unique functions of keratin 16 are likely determined by its tail domain, challenging the previous hypothesis about the role of the helix 1B subdomain.

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This study found that keratin K17 is induced in the suprabasal layer of psoriatic scalp epidermis during epidermal hyperproliferation, suggesting it is not specific to hair follicles.

research A Group of Type I Keratin Genes on Human Chromosome 17: Characterization and Expression

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This study found that despite strong homology between two K16 genes, only one encoded a functional protein that assembled into keratin filaments in epithelial cells, possibly due to promoter strength differences.

research Keratins of the Human Hair Follicle: Hyperproliferative Keratins Consistently Expressed in Outer Root Sheath Cells In Vivo and In Vitro

135 citations , November 1987 in “Differentiation”

This study found that cultured outer root sheath cells from human hair follicles expressed a keratin profile similar to their in vivo environment, indicating environmental influence on keratin expression.

research Three cDNA Sequences of Mouse Type I Keratins: Cellular Localization of the mRNAs in Normal and Hyperproliferative Tissues

57 citations , January 1987 in “Journal of Biological Chemistry”

This study identified and sequenced several keratin cDNA clones showing distinct expression patterns in mouse epithelia, with in situ hybridization highlighting differences in keratin distribution between normal and hyperproliferative tissues.