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research Structure of Intermediate Filament Assembly in Hair Deduced from Hydration Studies Using Small-Angle Neutron Scattering

9 citations , April 2019 in “Journal of structural biology”

Hair's internal fibers are arranged in a pattern that doesn't let much water in, and treatments like oils and heat change how much water hair can absorb.

research A General Mathematical Model for the In Vitro Assembly Dynamics of Intermediate Filament Proteins

5 citations , February 2022 in “Biophysical journal”

The model shows that filament flexibility and amino acid differences affect how fast intermediate filament proteins assemble.

research Complete Structure of an Epithelial Keratin Dimer: Implications for Intermediate Filament Assembly

42 citations , July 2015 in “PLoS ONE”

The study revealed the detailed structure of a keratin dimer, aiding understanding of how intermediate filament proteins function.

research Mutations in the Helix Termination Motif of Mouse Type I IRS Keratin Genes Impair the Assembly of Keratin Intermediate Filament

27 citations , November 2007 in “Genomics”

Mutations in specific keratin genes cause improper hair structure in mice due to faulty keratin protein assembly.

research CDNA Cloning, Expression, And Assembly Characteristics Of Mouse Keratin 16

32 citations , November 1998 in “Journal of Biological Chemistry”

Mouse and human keratin 16 can both form filaments, with differences likely due to the tail domain, not the helical domain.

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Community Join

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community Common hair-loss drug consistently associated with higher rates of psychiatric harm

in Research/Science 183 upvotes 2 months ago

Finasteride and dutasteride can cause psychiatric side effects like depression and suicidal thoughts in some users, especially those with a history of mental health issues. While some users experience positive hair growth results, others face severe psychological effects, raising concerns about their safety and the need for careful monitoring.

community Nov 2023 to today. 1mg finasteride daily since Feb 2024. Considering moving to Dutasteride based on the anecdotes I see on this sub and would like input.

in Progress Pictures 260 upvotes 11 months ago

A 30-year-old is using 1mg finasteride daily and 5% minoxidil inconsistently for hair regrowth, noticing recent progress and considering switching to dutasteride. Users advise continuing the current regimen for at least two years before considering dutasteride, as finasteride and minoxidil are showing positive results.

community New baby hairs are popping out. Question though: what are these black dots on hairline? Clogged pores?

in Finasteride/Dutasteride 39 upvotes 5 months ago

The user is experiencing new hair growth after using oral dutasteride, topical minoxidil, and microneedling, but is concerned about black dots on the hairline, which might be clogged pores or dormant follicles. The user previously used a topical minoxidil/finasteride spray and had good results, despite a shedding phase after switching treatments.

community Not all generic medications are made equal. Some work great, some weaker, and some are dangerous. What Pharmaceutical makes your current/past generic Finasteride?

in Finasteride/Dutasteride 6 upvotes 4 years ago

The conversation discusses the variability in effectiveness and safety of generic finasteride from different manufacturers, with some generics potentially containing impurities. Users shared their experiences with various brands, questioning if different brands affect hair loss treatment outcomes.