The Expanding Significance of Keratin Intermediate Filaments in Normal and Diseased Epithelia

    December 2012 in “ Current opinion in cell biology ”
    Xiaoou Pan, Ryan P. Hobbs, Pierre A. Coulombe
    Studysummary This review discusses the recent advancements in understanding how keratins influence cytoarchitecture, cell dynamics, and disease processes but reports no new clinical results; the authors highlight its roles in development and diseases like cancer.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 11

    1. Type I Keratin 17 Protein Is Phosphorylated on Serine 44 by p90 Ribosomal Protein S6 Kinase 1 in a Growth- and Stress-Dependent Fashion Journal of biological chemistry/˜The œJournal of biological chemistry · 2011
    2. Keratin Disorders: From Gene to Therapy Human molecular genetics online/Human molecular genetics · 2011
    3. Keratin Gene Mutations in Disorders of Human Skin and Its Appendages Archives of Biochemistry and Biophysics · 2010
    4. Keratins in Health and Cancer: More Than Mere Epithelial Cell Markers Oncogene · 2010
    5. Epidermolysis Bullosa Simplex: A Paradigm for Disorders of Tissue Fragility ˜The œJournal of clinical investigation/˜The œjournal of clinical investigation · 2009
    6. The Human Keratins: Biology And Pathology Histochemistry and Cell Biology · 2008
    7. Keratin 17 Modulates Hair Follicle Cycling in a TNFα-Dependent Fashion Genes & Development · 2006
    8. Keratin 17 Null Mice Exhibit Age- And Strain-Dependent Alopecia Genes & Development · 2002
    9. Discovery of a Novel Murine Keratin 6 (K6) Isoform Explains the Absence of Hair and Nail Defects in Mice Deficient for K6a and K6b The Journal of Cell Biology · 2001
    10. The Two Functional Keratin 6 Genes of Mouse Are Differentially Regulated and Evolved Independently from Their Human Orthologs Genomics · 1998
    11. Keratin Expression in Basal Cell Carcinomas British Journal of Dermatology · 1992

    Related research 1

    1. Hard and Soft Principles Defining the Structure, Function, and Regulation of Keratin Intermediate Filaments Current Opinion in Cell Biology · 2002