Keratin Function and Regulation in Tissue Homeostasis and Pathogenesis

    April 2012 in “ Biomolecular concepts ”
    Wera Roth, Meçhthild Hatzfeld, M. Friedrich, Sören Thiering, Thomas M. Magin
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    TLDR Keratin is crucial for keeping skin cells healthy and its changes can lead to diseases and affect cell behavior.
    The document from April 1, 2012, discusses the role of keratin intermediate filament proteins in maintaining epithelial integrity and their emerging involvement in growth control and organelle functions. It highlights that mutations or posttranslational modifications of the keratin cytoskeleton can make epithelia vulnerable to damage and stress, and that a loss of keratin expression is indicative of epithelial-mesenchymal transition (EMT). The paper emphasizes the complexity of understanding the molecular mechanisms of keratin functions, and it reviews how the cell-specific expression of keratin isotypes influences cytoarchitecture and cell behavior, as well as how posttranslational modifications affect keratin organization and interactions during signaling. It also discusses the pathomechanisms of epidermal keratin disorders based on new data and suggests future research directions to answer unresolved questions.
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