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GlossaryEpithelial-Mesenchymal Transition (EMT)

cells change from stationary epithelial to mobile mesenchymal

Epithelial-Mesenchymal Transition (EMT) is a biological process where epithelial cells, which are usually stationary and form tight layers, transform into mesenchymal cells, which are more mobile and can migrate. This process is crucial in various physiological contexts, such as wound healing and embryonic development, but it also plays a role in pathological conditions like cancer metastasis and fibrosis.

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RSPO1-Mutated Keratinocytes From Palmoplantar Keratoderma Display Impaired Differentiation and Invasiveness: Implications for Squamous Cell Carcinoma Susceptibility in Patients With 46XX Disorder of Sexual Development

research RSPO1-Mutated Keratinocytes From Palmoplantar Keratoderma Display Impaired Differentiation and Invasiveness: Implications for Squamous Cell Carcinoma Susceptibility in Patients With 46XX Disorder of Sexual Development

5 citations, July 2022 in “Orphanet journal of rare diseases”

RSPO1 mutations in certain patients lead to skin cells that don't develop properly and are more likely to become invasive, increasing the risk of skin cancer.

research EMT-Inhibiting Transcription Factor Ovol2 Regulates Directional Cell Migration and Proliferation in Adult Skin Epithelia

April 2018 in “Journal of Investigative Dermatology”

Ovol2 is important for proper skin healing and hair growth.

research Drugs Targeting Epithelial–Mesenchymal Transition Molecules for Treatment of Lichen Planopilaris

3 citations, May 2022 in “Clinical and experimental dermatology”

Drugs targeting EMT molecules show promise for treating lichen planopilaris.

research Epithelial Mesenchymal Transition and Tissue Healing

August 2019 in “Journal of Medical Histology”

EMT helps heal tissues but can cause scarring and other issues if prolonged.

research Wnt1/β-Catenin Injury Response Activates the Epicardium and Cardiac Fibroblasts to Promote Cardiac Repair

248 citations, November 2011 in “The EMBO Journal”

Wnt1/βcatenin signaling is crucial for heart repair after injury.

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community TWIST-1 and the cure: Is it really that easy?

in Research/Science 283 upvotes 2 years ago

TWIST-1 gene's role in hair loss and potential as a treatment target. Inhibiting TWIST-1 may prolong hair growth and reduce hair follicle sensitivity to DHT.

community UPDATE: The theory that explains everything. Please help me make this big!

in Research/Science 449 upvotes 3 years ago

Hair loss theory involves 3alpha-hydroxysteroid reductase (3AHD) converting DHT to androstenol. Discussion explores potential treatments and encourages more research.