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GlossaryEpithelial-Mesenchymal Transition (EMT)

cells change from stationary epithelial to mobile mesenchymal

Epithelial-Mesenchymal Transition (EMT) is a biological process where epithelial cells, which are usually stationary and form tight layers, transform into mesenchymal cells, which are more mobile and can migrate. This process is crucial in various physiological contexts, such as wound healing and embryonic development, but it also plays a role in pathological conditions like cancer metastasis and fibrosis.

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signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

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research EMT Factors and Metabolic Pathways in Cancer

346 citations , April 2020 in “Frontiers in Oncology”

EMT and metabolic pathways help cancer cells resist treatment and spread.

RSPO1-Mutated Keratinocytes From Palmoplantar Keratoderma Display Impaired Differentiation and Invasiveness: Implications for Squamous Cell Carcinoma Susceptibility in Patients With 46XX Disorder of Sexual Development

research RSPO1-Mutated Keratinocytes From Palmoplantar Keratoderma Display Impaired Differentiation and Invasiveness: Implications for Squamous Cell Carcinoma Susceptibility in Patients With 46XX Disorder of Sexual Development

5 citations , July 2022 in “Orphanet journal of rare diseases”

RSPO1 mutations in certain patients lead to skin cells that don't develop properly and are more likely to become invasive, increasing the risk of skin cancer.

research EMT-Inhibiting Transcription Factor Ovol2 Regulates Directional Cell Migration and Proliferation in Adult Skin Epithelia

April 2018 in “Journal of Investigative Dermatology”

Ovol2 is important for proper skin healing and hair growth.

research HOTTIP Mediated Therapy Resistance in Glioma Cells Involves Regulation of EMT-Related miR-10b

10 citations , March 2022 in “Frontiers in Oncology”

HOTTIP and miR-10b contribute to glioma therapy resistance by affecting cell behavior, suggesting they could be targets for treatment.

research Drugs Targeting Epithelial–Mesenchymal Transition Molecules for Treatment of Lichen Planopilaris

3 citations , May 2022 in “Clinical and experimental dermatology”

Drugs targeting EMT molecules show promise for treating lichen planopilaris.

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community Very high testosterone and estradiol on finasterid 1 mg. Am I cooked?

in Finasteride/Dutasteride 1 upvotes 1 day ago

A 29-year-old male on 1 mg Finasteride for 3 months has experienced a significant increase in testosterone and estradiol levels, with no major side effects except slightly oilier skin and increased emotional sensitivity. The user is concerned about these hormonal changes and seeks advice, as their general practitioner is not knowledgeable about the issue.

community I ended up in the ER due to oral Minoxodil.

in Minoxidil 7 upvotes 2 years ago

A user experienced severe side effects, including heart issues, after taking oral minoxidil without consulting a doctor. They are now considering alternatives like dutasteride, PRP, or laser treatments for hair loss.

community TWIST-1 and the cure: Is it really that easy?

in Research/Science 283 upvotes 3 years ago

TWIST-1 gene's role in hair loss and potential as a treatment target. Inhibiting TWIST-1 may prolong hair growth and reduce hair follicle sensitivity to DHT.

community UPDATE: The theory that explains everything. Please help me make this big!

in Research/Science 447 upvotes 4 years ago

Hair loss theory involves 3alpha-hydroxysteroid reductase (3AHD) converting DHT to androstenol. Discussion explores potential treatments and encourages more research.