Drugs Targeting Epithelial–Mesenchymal Transition Molecules for Treatment of Lichen Planopilaris

May 2022 in “ Clinical and experimental dermatology ”

Jessika Sanz, Deborah Lin, Mariya Miteva

lichen planopilaris primary cicatricial alopecia hair follicles epithelial-mesenchymal transition follicular stem cells pioglitazone tofacitinib barcitinib apremilast LPP scarring alopecia hair loss EMT stem cells

Studysummary This review discusses potential EMT-targeting drugs for treating lichen planopilaris and emphasizes the need for clinical trials, as current evidence is limited to individual cases or case series.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

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Research cited in this study

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research Hair Loss in Lichen Planopilaris and Frontal Fibrosing Alopecia: Not Always Irreversible

9 citations , January 2020 in “Skin appendage disorders”

This case report presents two instances where typically irreversible lichen planopilaris and frontal fibrosing alopecia showed signs of hair regrowth and symptom improvement following specific treatments.

research Frontal Fibrosing Alopecia: An Update on the Hypothesis of Pathogenesis and Treatment

38 citations , January 2019 in “International Journal of Women's Dermatology”

This review discusses potential therapeutic options for frontal fibrosing alopecia by exploring distinct signaling pathways and cellular players, but reports no new clinical findings and emphasizes the need for further trials.

research Tofacitinib for the Treatment of Lichen Planopilaris: A Case Series

79 citations , September 2018 in “Dermatologic therapy”

This study found that treatment with oral tofacitinib, alone or with other therapies, was associated with clinical improvement in most patients with recalcitrant lichen planopilaris.

research Lichen Planopilaris and Frontal Fibrosing Alopecia as Model Epithelial Stem Cell Diseases

80 citations , April 2018 in “Trends in Molecular Medicine”

This review discusses the roles of interferon-γ and PPAR-γ-mediated signalling in scarring alopecia, suggesting these pathways as potential therapeutic targets, but it reports no new empirical results.

research Epithelial-To-Mesenchymal Stem Cell Transition In A Human Organ: Lessons From Lichen Planopilaris

71 citations , October 2017 in “Journal of Investigative Dermatology”

PPAR-γ agonists like pioglitazone may help manage lichen planopilaris but don't fully reverse scarring.

research The Use of Oral Pioglitazone in the Treatment of Lichen Planopilaris

58 citations , January 2015 in “Journal of the American Academy of Dermatology”

Pioglitazone may help treat lichen planopilaris, but more research is needed.

Lichen Planopilaris Treated by the Peroxisome Proliferator-Activated Receptor-γ Agonist Pioglitazone: Lack of Lasting Improvement or Cure in the Majority of Patients

research Lichen Planopilaris Treated by the Peroxisome Proliferator-Activated Receptor-γ Agonist Pioglitazone: Lack of Lasting Improvement or Cure in the Majority of Patients

33 citations , October 2013 in “Journal of The American Academy of Dermatology”

In this study, pioglitazone treatment in patients with lichen planopilaris showed limited success, with significant improvement seen in only a minority of cases.

research Lichen Planopilaris Is Characterized By Immune Privilege Collapse Of The Hair Follicle's Epithelial Stem Cell Niche

220 citations , June 2013 in “The Journal of Pathology”

This study found that immune privilege collapse in the hair follicle bulge and associated immune responses may contribute significantly to the pathogenesis of lichen planopilaris, suggesting a potential autoimmune basis for the disease.

research Lichen Planopilaris: Retrospective Study and Stepwise Therapeutic Approach

43 citations , March 2009 in “Archives of dermatology”

No treatment showed clear superiority for lichen planopilaris.