An Update of the Pathogenesis of Frontal Fibrosing Alopecia: What Does the Current Evidence Tell Us?

    October 2018 in “ Australasian Journal of Dermatology ”
    Louise Photiou, Rosemary Nixon, Mei Tam, Jack Green, Leona Yip
    Image of study
    TLDR The current understanding of frontal fibrosing alopecia involves immune, genetic, hormonal factors, and possibly environmental triggers, but more research is needed for effective treatments.
    The document from 2018 reviews the complex pathogenesis of frontal fibrosing alopecia (FFA), highlighting the role of immune-mediated inflammation, genetic predisposition, hormonal influences, and potential environmental triggers. It notes that Th1-mediated inflammation, PPAR-y depletion, and epithelial-mesenchymal transition are key in the destruction of hair follicles. The condition's association with postmenopausal women and its coexistence with pattern hair loss in both genders suggest hormonal factors, with some response to 5x-reductase inhibitors. A retrospective review included 343 women and 12 men, indicating a significant overlap with pattern hair loss. The review underscores the lack of conclusive evidence for environmental triggers like sun exposure and calls for more research to fully understand FFA and develop effective treatments.
    Discuss this study in the Community →

    Research cited in this study

    20 / 20 results

    Related Community Posts Join

    6 / 355 results
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 1 month ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Opinions on Scalp fibrosis and DHT?

      in Research/Science  9 upvotes 2 years ago
      The conversation discusses the theory that scalp fibrosis contributes to male pattern baldness (MPB) by increasing DHT concentration, and mentions treatments like Minoxidil. The user seeks opinions on the theory and the effectiveness of scalp massages.

      community How I started reversing Male Pattern Baldness naturally ?

      in Question  6 upvotes 7 years ago
      The user reversed male pattern baldness using a pro-thyroid diet, lifestyle changes, and scalp stimulation exercises, without Minoxidil or Finasteride. They reported reduced dandruff, itchiness, oiliness, and experienced hair regrowth and thickening over 15 months.

      community Fibrosing alopecia in a pattern distribution

      in Research/Science  14 upvotes 6 months ago
      A user has been experiencing hair loss for 4 years, with treatments like minoxidil, finasteride, and various supplements proving ineffective. They were diagnosed with fibrosing alopecia in a pattern distribution, a condition that may require a combination of anti-inflammatory and hair growth treatments.

      community Where to Begin with Microneedling?

      in Treatment  17 upvotes 11 months ago
      User is considering microneedling to enhance hair regrowth after limited response to minoxidil and better results with finasteride and ketoconazole shampoo. Recommendations include using a 1.5mm derma roller once a week, avoiding minoxidil on microneedling days, and disinfecting the roller with isopropyl alcohol.

    Related Research

    3 / 3 results