Tissue and Circulating MicroRNA Co-expression Analysis Shows Potential Involvement of miRNAs in the Pathobiology of Frontal Fibrosing Alopecia

    July 2017 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    Christos Tziotzios, Chrysanthi Ainali, Susan Holmes, Fiona Cunningham, Su M. Lwin, Ιούλιος Παλαμάρας, Kapil Bhargava, Janice Rymer, Catherine M. Stefanato, Niall Kirkpatrick, Sérgio Vañó-Galván, Christos Petridis, David A. Fenton, Michael A. Simpson, Alexandros Onoufriadis, John A. McGrath
    TLDR Certain microRNAs might help identify and understand Frontal Fibrosing Alopecia.
    The study investigated the role of microRNAs (miRNAs) in the pathobiology of frontal fibrosing alopecia (FFA) by analyzing tissue and circulating miRNA co-expression in FFA patients and matched controls. It identified 55 up-regulated and 11 down-regulated miRNAs in FFA, with four circulating miRNAs—hsa-let-7d-5p, hsa-miR-18a-5p, has-miR-20a-5p, and hsa-miR-19a-3p—being highly predictive of FFA status. These miRNAs co-targeted similar gene sets, implicating pathways such as MAPK signaling, endocytosis, and focal adhesion in FFA. The findings suggested that these miRNAs could serve as potential biomarkers for FFA, though further functional validation was needed.
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