TLDR Certain microRNAs might help identify and understand Frontal Fibrosing Alopecia.
The study investigated the role of microRNAs (miRNAs) in the pathobiology of frontal fibrosing alopecia (FFA) by analyzing tissue and circulating miRNA co-expression in FFA patients and matched controls. It identified 55 up-regulated and 11 down-regulated miRNAs in FFA, with four circulating miRNAs—hsa-let-7d-5p, hsa-miR-18a-5p, has-miR-20a-5p, and hsa-miR-19a-3p—being highly predictive of FFA status. These miRNAs co-targeted similar gene sets, implicating pathways such as MAPK signaling, endocytosis, and focal adhesion in FFA. The findings suggested that these miRNAs could serve as potential biomarkers for FFA, though further functional validation was needed.
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May 2016 in “Experimental dermatology” FFA's causes may include environmental triggers and genetic factors.
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January 1997 in “Journal of the American Academy of Dermatology” Frontal fibrosing alopecia is a hair loss condition in postmenopausal women, similar to lichen planopilaris, with ineffective treatments.
325 citations
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June 1994 in “Archives of Dermatology” Postmenopausal frontal fibrosing alopecia may be a unique condition linked to postmenopausal changes.
September 2017 in “Journal of Investigative Dermatology” Certain miRNAs might be involved in a hair loss condition called frontal fibrosing alopecia and could possibly help in its diagnosis.
September 2017 in “Journal of Investigative Dermatology” Finasteride helps female-pattern hair loss.
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September 2017 in “Journal of Investigative Dermatology” The study found that sweat glands normally suppress immune responses, but this is disrupted in certain skin diseases, possibly contributing to their development.
September 2017 in “Journal of Investigative Dermatology” Researchers created human cells that can turn into sebocytes, which may help study and treat skin conditions like acne.
