11β-Hydroxysteroid Dehydrogenase Type 1 Inhibition Attenuates the Adverse Effects of Glucocorticoids on Dermal Papilla Cells
September 2017
in “
Journal of Investigative Dermatology
”
Studysummary The researchers reported that inhibiting 11β-HSD1 activity in human dermal papilla cells may reduce the negative effects of glucocorticoids on hair growth, suggesting potential treatment for stress-related hair loss.
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The study explored the role of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) in human dermal papilla cells (DPCs) and its inhibition as a potential treatment for stress-related hair loss. It was found that cortisol, a glucocorticoid, increases 11β-HSD1 expression in DPCs and reduces their proliferation and the expression of key factors like Wnt5a, alkaline phosphatase (ALP), and vascular endothelial growth factor (VEGF). However, using a selective 11β-HSD1 inhibitor significantly mitigated cortisol's negative effects on cell proliferation and the expression of these factors. The study concludes that 11β-HSD1 inhibitors may help prevent the adverse effects of glucocorticoids on DPCs, indicating their potential as a treatment for stress-related hair loss. The number of participants in the study was not provided.
