11β-Hydroxysteroid Dehydrogenase Type 1 Inhibition Attenuates the Adverse Effects of Glucocorticoids on Dermal Papilla Cells

    January 2017 in “ Yonsei Medical Journal ”
    Sang Eun Lee, Eun Young Lee, Sang Jin Kang, Seung Hun Lee
    Studysummary This study found that inhibiting 11β-HSD1 can partially reverse the negative impact of glucocorticoids on dermal papilla cells in human scalps, suggesting potential for treating stress-related hair loss.
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    Research cited in this study 14

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    2. Hair Loss And Hypothalamic-Pituitary-Adrenocortical Axis Activity In Captive Rhesus Macaques (Macaca Mulatta) PubMed · 2014
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    7. Molecular Dissection of Mesenchymal–Epithelial Interactions in the Hair Follicle PLoS biology · 2005
    8. Human Hair Follicles Display a Functional Equivalent of the Hypothalamic-Pituitary-Adrenal (HPA) Axis and Synthesize Cortisol The FASEB Journal · 2005
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    13. A Murine Model for Inducing and Manipulating Hair Follicle Regression: Effects of Dexamethasone and Cyclosporin A Journal of Investigative Dermatology · 1994
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    Related research 1

    1. 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibition Attenuates the Adverse Effects of Glucocorticoids on Dermal Papilla Cells Yonsei Medical Journal · 2017