11β-Hydroxysteroid Dehydrogenase Type 1 Inhibition Attenuates the Adverse Effects of Glucocorticoids on Dermal Papilla Cells

January 2017 in “ Yonsei Medical Journal ”

Sang Eun Lee, Eun Young Lee, Sang Jin Kang, Seung Hun Lee

11β-Hydroxysteroid Dehydrogenase Type 1 11β-HSD1 glucocorticoids dermal papilla cells DPCs hair growth Wnt5a alkaline phosphatase ALP vascular endothelial growth factor VEGF 11β-HSD1 inhibitor stress-related hair loss

TLDR Blocking 11β-HSD1 can lessen the harmful effects of glucocorticoids on hair growth cells.

The study from 2017 explored the expression of 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) in human dermal papilla cells (DPCs) and its potential as a target to counteract the negative effects of glucocorticoids on hair growth. Glucocorticoids, which are known to inhibit hair growth, increase the expression of 11β-HSD1 in DPCs. The researchers discovered that treatment with glucocorticoids decreased cell proliferation and the expression of hair growth markers such as Wnt5a, alkaline phosphatase (ALP), and vascular endothelial growth factor (VEGF) in DPCs. However, using a selective 11β-HSD1 inhibitor significantly reduced these adverse effects, suggesting that such inhibitors could be a therapeutic option for stress-related hair loss. The number of participants or samples used in the study was not mentioned in the summary.

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