11β-Hydroxysteroid Dehydrogenase Type 1 Inhibition Attenuates the Adverse Effects of Glucocorticoids on Dermal Papilla Cells

January 2017 in “ Yonsei Medical Journal ”

Sang Eun Lee, Eun Young Lee, Sang Jin Kang, Seung Hun Lee

11β-Hydroxysteroid Dehydrogenase Type 1 11β-HSD1 glucocorticoids dermal papilla cells DPCs hair growth Wnt5a alkaline phosphatase ALP vascular endothelial growth factor VEGF 11β-HSD1 inhibitor stress-related hair loss

Studysummary This study found that inhibiting 11β-HSD1 can partially reverse the negative impact of glucocorticoids on dermal papilla cells in human scalps, suggesting potential for treating stress-related hair loss.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The study from 2017 explored the expression of 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) in human dermal papilla cells (DPCs) and its potential as a target to counteract the negative effects of glucocorticoids on hair growth. Glucocorticoids, which are known to inhibit hair growth, increase the expression of 11β-HSD1 in DPCs. The researchers discovered that treatment with glucocorticoids decreased cell proliferation and the expression of hair growth markers such as Wnt5a, alkaline phosphatase (ALP), and vascular endothelial growth factor (VEGF) in DPCs. However, using a selective 11β-HSD1 inhibitor significantly reduced these adverse effects, suggesting that such inhibitors could be a therapeutic option for stress-related hair loss. The number of participants or samples used in the study was not mentioned in the summary.

View this study on eymj.org →

Discuss this study in the Community →

Research cited in this study

14 / 14 results

research Stress-Related Skin Disorders

67 citations , July 2016 in “Reviews in Endocrine and Metabolic Disorders”

This review discusses the complex relationship between stress and various skin conditions, highlighting the role of the skin in the stress response and the brain-skin communication pathways, but reports no new research findings.

research Hair Loss And Hypothalamic-Pituitary-Adrenocortical Axis Activity In Captive Rhesus Macaques (Macaca Mulatta)

28 citations , May 2014 in “PubMed”

This study found that increased hair cortisol levels, indicating stress, were associated with greater hair loss in captive rhesus macaques, although the causality of this relationship remains unclear.

research Effects of Glucocorticoid on Human Dermal Papilla Cells In Vitro

27 citations , December 2012 in “The Journal of Steroid Biochemistry and Molecular Biology”

This study found that dexamethasone treatment reduced cell viability and growth factor expression in human dermal papilla cells, suggesting it inhibits hair growth.

research Localization, Age- and Site-Dependent Expression, and Regulation of 11β-Hydroxysteroid Dehydrogenase Type 1 in Skin

119 citations , August 2010 in “Journal of Investigative Dermatology”

This study reports that 11β-HSD1 activity in human skin increases with age and photoexposure, potentially contributing to skin aging and the effects of glucocorticoids.

research Review of Hair Follicle Dermal Cells

321 citations , December 2009 in “Journal of Dermatological Science”

This review discusses the role of dermal cells in hair follicle regeneration and morphogenesis and highlights their potential therapeutic implications, but it reports no new empirical findings.

research Hair Growth Inhibition by Psychoemotional Stress: A Mouse Model for Neural Mechanisms in Hair Growth Control

127 citations , December 2005 in “Experimental Dermatology”

This study provides evidence that psychoemotional stress inhibits hair growth in mice by affecting the brain-hair follicle axis, with specific neuropeptides and treatments modulating this effect.

research Molecular Dissection of Mesenchymal–Epithelial Interactions in the Hair Follicle

417 citations , September 2005 in “PLoS biology”

This study developed molecular signatures for dermal papilla cells and their niche, uncovering novel signaling regulators and genes linked to hair disorders, which may inform future hair development research.

research Human Hair Follicles Display a Functional Equivalent of the Hypothalamic-Pituitary-Adrenal (HPA) Axis and Synthesize Cortisol

489 citations , June 2005 in “The FASEB Journal”

This study found that human scalp hair follicles can respond to corticotropin releasing hormone stimulation similarly to the classical HPA axis, including up-regulating cortisol production and activating neuroendocrine feedback loops.

Cultured Peribulbar Dermal Sheath Cells Can Induce Hair Follicle Development and Contribute to the Dermal Sheath and Dermal Papilla

research Cultured Peribulbar Dermal Sheath Cells Can Induce Hair Follicle Development and Contribute to the Dermal Sheath and Dermal Papilla

208 citations , December 2003 in “Journal of Investigative Dermatology”

This study found that dermal papilla and peribulbar dermal sheath cup cells in mice can both induce hair follicle formation, suggesting they may have similar functional roles in hair growth.

research Stress And The Hair Follicle

61 citations , March 2003 in “American Journal Of Pathology”

Stress can cause hair loss and skin issues by affecting hair growth cycles.

research Altered Skin Development and Impaired Proliferative and Inflammatory Responses in Transgenic Mice Overexpressing the Glucocorticoid Receptor

92 citations , July 2001 in “The FASEB Journal”

In this study, transgenic mice overexpressing the glucocorticoid receptor in certain epithelia showed skin development abnormalities resembling ectodermal dysplasia and exhibited reduced inflammatory responses.

research Regulation of Human Dermal Papilla Cell Production of Insulin-Like Growth Factor Binding Protein-3 by Retinoic Acid, Glucocorticoids, and Insulin-Like Growth Factor-1

37 citations , June 1996 in “Journal of cellular physiology”

This study found that IGF1, retinoic acid, and dexamethasone increase IGFBP-3 production in cultured human dermal papilla cells, potentially inhibiting IGF1 action on hair growth.

research A Murine Model for Inducing and Manipulating Hair Follicle Regression: Effects of Dexamethasone and Cyclosporin A

124 citations , August 1994 in “Journal of Investigative Dermatology”

This study found that applying dexamethasone to mice induced catagen-like follicle changes significantly earlier and more consistently than a vehicle, such changes being useful for studying hair follicle regression.

Effects of Epidermal Growth Factor, Fibroblast Growth Factor, Minoxidil, and Hydrocortisone on Growth Kinetics in Human Hair Bulb Papilla Cells and Root Sheath Fibroblasts Cultured In Vitro

research Effects of Epidermal Growth Factor, Fibroblast Growth Factor, Minoxidil, and Hydrocortisone on Growth Kinetics in Human Hair Bulb Papilla Cells and Root Sheath Fibroblasts Cultured In Vitro

58 citations , June 1987 in “Archives of Dermatological Research”

This study found that epidermal and fibroblast growth factors increased proliferation of human hair bulb papilla cells and root sheath fibroblasts in vitro, while hydrocortisone decreased it and minoxidil had no effect.