Hair Loss in Lichen Planopilaris and Frontal Fibrosing Alopecia: Not Always Irreversible

    January 2020 in “ Skin appendage disorders ”
    Prag Batra, Kumar Sukhdeo, Jerry Shapiro
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    TLDR Hair loss from conditions like LPP and FFA can potentially be reversed with the right treatment.
    In 2019, a study reported two cases of typically irreversible hair loss conditions, lichen planopilaris (LPP) and frontal fibrosing alopecia (FFA), showing signs of reversal. A 27-year-old man with LPP experienced hair regrowth and elimination of itch six months after adding oral tofacitinib and dapsone to his treatment. A 45-year-old woman with FFA showed hair and eyebrow regrowth and reduction in glabella-hairline distance over six months after starting oral finasteride and hydroxychloroquine, triamcinolone injections, and topical minoxidil. The study concluded that LPP and FFA might be reversible with appropriate therapy, with LPP responding to tofacitinib and dapsone, and FFA responding to androgenic and immune modulators.
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      A user has been experiencing hair loss for 4 years, with treatments like minoxidil, finasteride, and various supplements proving ineffective. They were diagnosed with fibrosing alopecia in a pattern distribution, a condition that may require a combination of anti-inflammatory and hair growth treatments.
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      in Research  692 upvotes 3 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

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      in Chat  10 upvotes 2 weeks ago
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      in Research/Science  81 upvotes 1 year ago
      The conversation is about the role of testosterone in hair loss and the effectiveness of different treatments. The conclusion is that DHT is the main culprit for hair loss, and finasteride has been proven to work long-term in maintaining and regrowing hair. Testosterone may have a minor effect, but it is not the primary cause of hair loss.

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      in Treatment  60 upvotes 1 year ago
      Treating the itch associated with male pattern baldness, which is believed to be caused by DHT. Potential treatments discussed include salt water, finasteride, ketoconazole, and RU58841.

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      in Chat  33 upvotes 2 years ago
      Lichen Planopilaris (LPP), a form of permanent hair loss, which can be mistaken for seborrheic dermatitis and is characterized by scalp itching, burning, redness, and dandruff. Treatment options discussed include steroidal creams, finasteride, minoxidil, and RU58841.

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