Prognosis, Treatment, and Disease Outcomes in Frontal Fibrosing Alopecia: A Retrospective Review of 92 Cases

    Lauren C. Strazzulla, Lorena Avila, Xiaoxue Li, Kristen Lo Sicco, Jerry Shapiro
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    TLDR Most patients with frontal fibrosing alopecia stabilized with treatment, especially younger ones, using intralesional corticosteroids and tacrolimus.
    This retrospective review of 92 patients with frontal fibrosing alopecia (FFA) found that 70.7% of patients stabilized with treatment after an average of 10.4 months. The study identified that a younger age of onset was associated with a less severe disease course. Most patients (71.7%) were treated with intralesional corticosteroids combined with topical and systemic agents. Tacrolimus was found to be more effective in achieving stabilization within 3 months compared to clobetasol/betamethasone. Adverse effects were more common in patients treated with doxycycline, tetracycline, or minocycline. Limitations included the retrospective design and small sample size.
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