A New Histologic Pattern in 6 Biopsies From Early Frontal Fibrosing Alopecia

August 2018 in “ The American Journal of Dermatopathology ”

Mariya Miteva, Samar Sabiq

Frontal Fibrosing Alopecia FFA inflammatory vellus involvement trichoscopy vellus follicles atrophied sebaceous glands perifollicular lymphohistiocytic infiltrate perifollicular fibrosis lichenoid inflammation

Studysummary This study describes a newly observed "inflammatory vellus involvement" pattern in early frontal fibrosing alopecia, which may lead to misdiagnosis due to the absence of typical histological features.

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research Lichen Planopilaris and Frontal Fibrosing Alopecia as Model Epithelial Stem Cell Diseases

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This review discusses the roles of interferon-γ and PPAR-γ-mediated signalling in scarring alopecia, suggesting these pathways as potential therapeutic targets, but it reports no new empirical results.

research It's Not All Traction: The Pseudo 'Fringe Sign' in Frontal Fibrosing Alopecia

39 citations , July 2015 in “British Journal of Dermatology”

This article discusses the pseudo 'fringe sign' in frontal fibrosing alopecia, highlighting that it is not solely related to traction, and it reports no new clinical results.

research Absence of Vellus Hair in the Hairline: A Videodermatoscopic Feature of Frontal Fibrosing Alopecia

33 citations , August 2013 in “British Journal of Dermatology”

Lack of small, fine hair on the front hairline is a key sign of frontal fibrosing alopecia.

research Acute Hair Loss on the Limbs in Frontal Fibrosing Alopecia: A Clinicopathological Study of Two Cases

31 citations , April 2010 in “British journal of dermatology/British journal of dermatology, Supplement”

This report describes two patients with frontal fibrosing alopecia who developed acute hair loss on their limbs, revealing that the limb alopecia had similar histological features to scalp alopecia.

research Expression of Snail1 in the Fibrotic Dermis of Postmenopausal Frontal Fibrosing Alopecia: Possible Involvement of an Epithelial-Mesenchymal Transition and a Review of Japanese Patients

29 citations , February 2010 in “British Journal of Dermatology”

This study explores the expression of Snail1 in the fibrotic dermis of postmenopausal women with frontal fibrosing alopecia, suggesting a possible link to epithelial-mesenchymal transition.

research Frontal Fibrosing Alopecia Versus Lichen Planopilaris: A Clinicopathological Study

126 citations , April 2006 in “International Journal of Dermatology”

This study found that frontal fibrosing alopecia and lichen planopilaris have similar histopathological features, but FFA exhibits more prominent apoptosis and less inflammation with spared interfollicular epidermis.

research Frontal Fibrosing Alopecia in Postmenopausal Women

179 citations , December 2004 in “Journal of The American Academy of Dermatology”

This study observed that frontal fibrosing alopecia in postmenopausal women involves selective follicular inflammation, and finasteride treatment may slow disease progression, suggesting a potential androgen-related component.

research Postmenopausal Frontal Fibrosing Alopecia: A Frontal Variant of Lichen Planopilaris

329 citations , January 1997 in “Journal of the American Academy of Dermatology”

This study reports that progressive frontal fibrosing alopecia, a distinct and gradually stabilizing form of lichen planopilaris affecting elderly women and often involving eyebrow hair loss, lacks effective treatments.