TLDR Snail1 may contribute to fibrosis in frontal fibrosing alopecia in postmenopausal women.
The study investigated the expression of Snail1 in the fibrotic dermis of postmenopausal women with frontal fibrosing alopecia (FFA) and suggested a possible involvement of epithelial-mesenchymal transition (EMT) in the disease's pathology. The research reviewed Japanese patients and found that Snail1, a transcription factor associated with EMT, was present in the fibrotic areas of the dermis. This finding indicated that EMT might play a role in the development of fibrosis in FFA, providing a potential target for future therapeutic strategies.
155 citations,
September 2008 in “British journal of dermatology/British journal of dermatology, Supplement” FFA is more common in postmenopausal women, can affect younger women, and may stabilize over time.
March 2005 in “Journal of the American Academy of Dermatology” Cosmetic treatments can replenish key amino acids in damaged hair, improving its strength and appearance.
57 citations,
January 2003 in “Clinical and experimental dermatology” Postmenopausal frontal fibrosing alopecia is a type of hair loss in postmenopausal women that may stop on its own but has no effective treatment.
49 citations,
January 2003 in “Clinical and Experimental Dermatology” The document concludes that post-menopausal frontal fibrosing alopecia is a poorly understood condition that does not respond well to common treatments.
80 citations,
April 2018 in “Trends in Molecular Medicine” Lichen Planopilaris and Frontal Fibrosing Alopecia may help us understand hair follicle stem cell disorders and suggest new treatments.
23 citations,
April 2021 in “Journal of Clinical Medicine” Frontal Fibrosing Alopecia's cause is unclear, affects mainly postmenopausal women, and current treatments focus on stopping hair loss rather than regrowth.
38 citations,
January 2019 in “International Journal of Women's Dermatology” The document concluded that more research is needed to find the best treatment for Frontal fibrosing alopecia.
7 citations,
August 2018 in “The American Journal of Dermatopathology” Researchers found a new early sign of Frontal Fibrosing Alopecia that could help avoid misdiagnosis.
11 citations,
April 2016 in “The American Journal of Dermatopathology” Special and immunohistochemical stains are not routinely needed for diagnosing hair disorders.
