Unveiling a Shared Precursor Condition for Acne Keloidalis Nuchae and Primary Cicatricial Alopecias

    Sanusi Umar, Donna Ton, Marissa J. Carter, Paul Shitabata
    Image of study
    TLDR A condition with certain scalp changes may come before acne keloidalis nuchae and other similar hair loss disorders.
    The retrospective study analyzed 41 men diagnosed with Acne keloidalis nuchae (AKN), a type of primary cicatricial alopecia. It found that a subclinical disease characterized by perifollicular infundibulo-isthmic lymphocytic infiltrates lamellar fibrosis (PIILIF), and sebaceous gland destruction may precede AKN lesions. All patients' normal-appearing-scalp zones showed PIILIF features, with 96% showing absence of Vellus or miniaturized hair. The study suggests that PIILIF may be a precursor to AKN and possibly other Primary Cicatricial Alopecias (PCAs). It also found a significant reduction in anagen: telogen-catagen ratios and a decrease in hair count between non-alopecic scalp and AKN. The study was limited by its retrospective nature and the fact it was performed in an AKN specialty clinic. Further studies are needed to confirm the association between PIILIF and other PCAs.
    Discuss this study in the Community →

    Research cited in this study

    24 / 24 results

    Related Community Posts Join

    6 / 727 results

      community Seeking Advice: Unusual Hair Loss at 31 Years Old - Any Insights? (M)

      in Chat  15 upvotes 1 year ago
      A 31-year-old man who previously had good results with minoxidil, finasteride, and nizoral for hair loss is now experiencing unusual hair loss and side effects from finasteride. Respondents suggest it might be severe retrograde alopecia and recommend exploring other treatment options due to his inability to tolerate finasteride.

      community biotin leads to acne and sebum on scalp ??

      in Finasteride/Dutasteride  1 upvotes 1 year ago
      User is experiencing increased sebum, dandruff, and acne after taking a supplement containing biotin, iron, zinc, and calcium pantothenate along with finasteride. They are questioning if biotin is the cause and whether they should stop taking it.

      community is anyone using ru58841 against acne?

      in Technology  3 upvotes 5 months ago
      RU58841 is discussed as a potential treatment for acne and hair loss, with users debating its effectiveness and safety compared to other treatments like finasteride, minoxidil, and dutasteride. Concerns about RU58841's side effects and lack of clinical trials are raised, while some users share their personal experiences and routines involving RU58841 for hair loss.

      community Using WinLevi (Clascoterone) for Seborrheic Dermatitis and Acne

      in Treatment  4 upvotes 1 year ago
      Winlevi (clascoterone) is discussed as a treatment for hormonal acne and seborrheic dermatitis due to its ability to block DHT and regulate sebum production. The post suggests that Winlevi could offer a novel approach for managing seborrheic dermatitis.

    Related Research

    2 / 2 results