Updates in Therapeutics for Folliculitis Decalvans: A Systematic Review with Evidence-Based Analysis

    March 2019 in “ Journal of the American Academy of Dermatology ”
    Pooja H. Rambhia, Rosalynn R.Z. Conic, Aizuri Murad, Natasha Atanaskova-Mesinkovska, Melissa Piliang, Wilma F. Bergfeld
    TLDR Clindamycin and rifampicin are the most effective treatments for folliculitis decalvans, but more research is needed.
    The systematic review on therapeutics for folliculitis decalvans (FD) analyzed 20 studies involving 282 patients and highlighted various treatment options, including antibiotics, corticosteroids, and biologics. Clindamycin and rifampicin showed the longest remission (7.2 months) in a multicenter study, but results varied, and relapses were common. Other treatments like doxycycline, azithromycin, and isotretinoin had mixed efficacy and side effects. Newer therapies like red light photodynamic therapy showed promise but had low evidence levels. The review concluded that more rigorous, large-scale randomized controlled trials were needed to establish the most effective treatments and develop standardized protocols.
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