Oral Isotretinoin as the Most Effective Treatment in Folliculitis Decalvans: A Retrospective Comparison of Different Treatment Regimens in 28 Patients

    February 2015 in “ Journal of the European Academy of Dermatology and Venereology ”
    Julia K. Tietze, Markus V. Heppt, Anna von Preußen, U. Wolf, Thomas Ruzicka, Hans Wolff, Elke Sattler
    TLDR Oral isotretinoin is the most effective treatment for folliculitis decalvans.
    The study retrospectively compared the efficacy of different treatment regimens in 28 patients with folliculitis decalvans, a condition leading to scarring alopecia. The treatments analyzed included clindamycin and rifampicin, clarithromycin, dapsone, and isotretinoin. Clindamycin and rifampicin had the lowest success rate, with 80% of patients relapsing shortly after treatment. Clarithromycin and dapsone had better outcomes, with long-term remission rates of 33% and 43%, respectively. Isotretinoin was the most effective, achieving stable remission in 90% of patients during and up to two years post-treatment. The study concluded that the common use of antibiotics as first-line therapy should be reconsidered, and oral isotretinoin should be considered a valid alternative.
    Discuss this study in the Community →

    Research cited in this study

    4 / 4 results

    Related Community Posts Join

    6 / 1000+ results
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 4 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community DHT levels after 4 weeks of Fina and 8 weeks of Fina + 4 weeks of Duta

      in Update  35 upvotes 5 years ago
      The user reported early stage diffuse hair thinning and increased DHT levels after 4 weeks on Finasteride and 8 weeks on Finasteride plus 4 weeks on Dutasteride, despite the medications being authentic and stored properly. They are considering increasing their Dutasteride dosage due to the lack of side effects and are unsure if the treatment is helping their hair.

      community Why is no one pointing out dandruff as the number 1 evidence/symptom of MPB?

      in Chat  55 upvotes 1 year ago
      The post discusses the theory that persistent dandruff in areas prone to hair loss could be a sign of hair follicles dying due to DHT, indicating balding. The responses vary, with some users noting improvements in dandruff and hair loss with treatments like Dutasteride, while others experienced hair loss without dandruff.

      community 1 year on Finasteride, 2 months on derma rolling and minoxidil

      in Progress Pictures  75 upvotes 1 year ago
      The user has been on Finasteride for over a year and recently added minoxidil and derma rolling to their regimen, experiencing side effects like headaches and acne for a few weeks. They tried various non-medication treatments for early-stage hair loss with no success before turning to medication, which improved their hair and confidence.

    Related Research

    1 / 1 results