Antiandrogenic Drugs: A Therapeutic Option for Frontal Fibrosing Alopecia Patients

In a letter to the editor, the authors responded to comments on their article regarding the use of oral antiandrogens (OA) for treating frontal fibrosing alopecia (FFA). They clarified that OA could benefit FFA patients without androgenetic alopecia (AGA), as observed in 10 FFA patients treated solely with OA in their study. Despite concerns about the adverse effects of OA, such as the risk of breast cancer, recent studies have supported the safety of these drugs. The authors also highlighted evidence suggesting a hormonal mechanism might be involved in FFA, noting the majority of cases occur in females, often during the perimenopausal period, and there is an increased incidence of early menopause and gynecologic surgeries in FFA patients. Preliminary results from their ongoing research suggest an impairment in sex-hormone signaling in FFA patients. They concluded that OA, with a known and acceptable adverse effect profile, could be an interesting therapeutic option for FFA patients.