Treatment-Refractory Central Centrifugal Cicatricial Alopecia Responsive to a Novel Botanical Treatment

April 2022 in “ Clinical, cosmetic and investigational dermatology ”

Sanusi Umar, Petrina Kan, Marissa J. Carter, Paul Shitabata

Central Centrifugal Cicatricial Alopecia CCCA botanical treatment Dr. UGro Gashee topical cosmeceutical oral nutraceutical phytoactive ingredients scalp pruritus hair regrowth UGro Gashee

TLDR A new plant-based treatment was effective for hair regrowth in women with a specific type of hair loss that didn't respond to usual treatments.

In a case series involving four African American women with treatment-refractory Central Centrifugal Cicatricial Alopecia (CCCA), a novel botanical treatment (Dr. UGro Gashee) was found to be effective. The treatment, which was used for a period ranging from 8 weeks to 1 year, included both a topical cosmeceutical and an oral nutraceutical containing similar phytoactive ingredients. The patients experienced cessation of scalp pruritus within 2 weeks and significant hair regrowth within 2 months, without any reported adverse effects. The study suggests that this botanical treatment could be a promising alternative for CCCA patients who do not respond to traditional therapies, though further research with a larger controlled trial is recommended.

View this study on dovepress.com →

Discuss this study in the Community →

Cited in this study

12 / 12 results

research Vitamin D Status in Scarring and Nonscarring Alopecia

13 citations , August 2021 in “Journal of The American Academy of Dermatology”

People with certain types of hair loss, especially lichen planopilaris and telogen effluvium, as well as African Americans, Asians, and men, are more likely to have severe vitamin D deficiency.

research A Multimodal Hair-Loss Treatment Strategy Using a New Topical Phytoactive Formulation: A Report of Five Cases

2 citations , February 2021 in “Case reports in dermatological medicine”

research The Use of Natural Ingredients in the Treatment of Alopecias with an Emphasis on Central Centrifugal Cicatricial Alopecia: A Systematic Review

3 citations , August 2020 in “PubMed”

Some natural ingredients like onion juice, rosemary oil, and pumpkin seed oil may help with hair growth and reducing hair loss.

research Hair Regrowth in Two Patients with Recalcitrant Central Centrifugal Cicatricial Alopecia After Use of Topical Metformin

24 citations , February 2020 in “JAAD Case Reports”

Topical metformin helped regrow hair in two women with a hard-to-treat scarring hair loss condition.

research Variant PADI3 in Central Centrifugal Cicatricial Alopecia

95 citations , February 2019 in “The New England Journal of Medicine”

Mutations in the PADI3 gene are linked to a higher risk of scarring hair loss in women of African descent.

research Current and Emerging Treatment Strategies for Hair Loss in Women of Color

15 citations , January 2019 in “International Journal of Women's Dermatology”

Early treatment helps stop hair loss in women of color.

research Fibroproliferative Genes Are Preferentially Expressed in Central Centrifugal Cicatricial Alopecia

25 citations , November 2018 in “Journal of The American Academy of Dermatology”

Genes linked to fibrosis are more active in people with central centrifugal cicatricial alopecia.

research Adipose and Hair Function: An Apparent Connection

7 citations , March 2018 in “Journal of Investigative Dermatology”

Fat tissue and a specific protein are crucial for healthy hair growth and maintenance.

research A Multicenter, Randomized, Placebo-Controlled, Double-Blind Clinical Trial of a Novel Formulation of 5% Minoxidil Topical Foam Versus Placebo in the Treatment of Androgenetic Alopecia in Men

142 citations , November 2007 in “Journal of The American Academy of Dermatology”

New 5% minoxidil foam effectively promotes hair growth and is safe for use.