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    GlossaryScalp Irritation (Scalp Pruritus)

    inflammation or discomfort on the scalp, often causing itching

    Scalp irritation refers to discomfort or inflammation of the scalp, often characterized by symptoms such as itching, redness, and sensitivity. It can be caused by various factors including allergic reactions to hair products, fungal infections, dandruff, or underlying skin conditions like psoriasis or eczema. Proper diagnosis and treatment are essential to alleviate symptoms and address the root cause.

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      learn HMI-115

      much-hyped research compound targeting prolactin receptor in scalp

      learn Platelet-Rich Plasma

      growth factors taken from your blood and injected into your scalp to stimulate hair

      learn GT20029

      research compound made to degrade androgen receptors in scalp

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      community Topical finasteride now the safest possible path?

      in Finasteride/Dutasteride  84 upvotes 11 months ago
      Topical finasteride is considered a safer option for hair regrowth with fewer systemic side effects compared to oral finasteride. Some users report similar efficacy and side effects between topical and oral treatments, while others prefer topical due to reduced systemic exposure.
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 10 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Don’t Get Too Hyped About PP405. We've Seen This Movie Before.

      in Research/Science  203 upvotes 1 week ago
      PP405 is a new hair loss treatment showing early promise with a 20% hair density increase, but skepticism exists due to past failures of similar treatments like Pyrilutamide, RU58841, and Bimatoprost. Users debate its potential effectiveness, with some hopeful due to Google's involvement, while others urge caution without more evidence.

      community Kintor Phase 2 Results released KX-826 (pyrilutamide)

      in Research/Science  447 upvotes 2 years ago
      Kintor Pharmaceutical's Phase 2 results with the drug Pyrilutamide, a potential alternative to 5-ARI drugs like Finasteride and Dutasteride but without the side effects. It could be used in combination with other topical treatments such as Minoxidil. The safety of the drug has been demonstrated in 6 months of use, however there are still questions about long term efficacy and systemic absorption.