The Use of Natural Ingredients in the Treatment of Alopecias with an Emphasis on Central Centrifugal Cicatricial Alopecia: A Systematic Review

August 2020 in “ PubMed ”

Nneamaka Ezekwe, Madelyn King, Jasmine C Hollinger

onion juice rosemary oil pumpkin seed oil alopecia areata androgenetic alopecia Central Centrifugal Cicatricial Alopecia CCCA azelaic acid garlic gel olive oil psoriatic alopecia minoxidil Rogaine

From the encyclopedia

Pumpkin seed oil →

Alopecia Areata →

autoimmune disorder causing patchy hair loss

Azelaic Acid →

acid used for antimicrobial, anti-inflammatory and anti-androgenic properties

Studysummary This review discusses the absence of clinical trials on natural ingredients for managing Central Centrifugal Cicatricial Alopecia and highlights a need for more research.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

In 2020, a systematic review explored the effectiveness of natural ingredients in treating various types of alopecia, with a focus on Central Centrifugal Cicatricial Alopecia (CCCA). The review found that onion juice, rosemary oil, and pumpkin seed oil showed potential in promoting hair growth and reducing hair loss. Onion juice was effective in treating alopecia areata, while rosemary oil was comparable to minoxidil in treating androgenetic alopecia. Pumpkin seed oil also showed potential in treating androgenetic alopecia. Other natural ingredients such as azelaic acid, garlic gel, and olive oil also showed efficacy in treating alopecia areata and psoriatic alopecia. Despite these promising results, the review emphasized the need for more rigorous clinical trials, especially for CCCA.

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Research cited in this study

13 / 13 results

research Management of Alopecia Areata: Updates and Algorithmic Approach

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research Rosemary Oil vs Minoxidil 2% for the Treatment of Androgenetic Alopecia: A Randomized Comparative Trial

10 citations , April 2015 in “PubMed”

This study found that rosemary oil and minoxidil 2% both increased hair count equally in patients with androgenetic alopecia after 6 months, with more scalp itching seen in the minoxidil group.

research Alopecia Areata: An Evidence-Based Treatment Update

72 citations , July 2014 in “American journal of clinical dermatology”

This review analyzed randomized controlled trials on alopecia areata treatment and found that while several treatments showed effectiveness, most studies had limitations affecting their interpretability.

research Effect of Pumpkin Seed Oil on Hair Growth in Men with Androgenetic Alopecia: A Randomized, Double-Blind, Placebo-Controlled Trial

36 citations , January 2014 in “Evidence-based Complementary and Alternative Medicine”

This study found that men with androgenetic alopecia treated with pumpkin seed oil for 24 weeks experienced a notable 40% increase in hair count compared to a 10% increase with a placebo.

Preparation and Evaluation of a Multimodal Minoxidil Microemulsion Versus Minoxidil Alone in the Treatment of Androgenic Alopecia of Mixed Etiology: A Pilot Study

research Preparation and Evaluation of a Multimodal Minoxidil Microemulsion Versus Minoxidil Alone in the Treatment of Androgenic Alopecia of Mixed Etiology: A Pilot Study

24 citations , May 2013 in “Drug Design Development and Therapy”

This pilot study found that a multimodal minoxidil microemulsion with diclofenac and tea tree oil was more effective and safer than minoxidil alone for treating androgenic alopecia over 32 weeks.

research Central Hair Loss in African American Women: Incidence and Potential Risk Factors

76 citations , November 2010 in “Journal of The American Academy of Dermatology”

In this study, a photographic scale and questionnaire revealed that extensive central scalp hair loss was observed in 5.6% of African American women, with an association to a history of tinea capitis.

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This article discusses diagnostic challenges and management approaches for hair loss in women of color, emphasizing the importance of clinical examinations and education to prevent and manage traction alopecia.

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research Hot Comb Alopecia

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In this study, irreversible alopecia on the crown of the scalp in Black women using hot combs was associated with chronic inflammation and follicle damage leading to scarring.