Adipose and Hair Function: An Apparent Connection

    February 2018 in “ Journal of Investigative Dermatology ”
    Nasif Islam, Luis A. Garza
    Image of study
    TLDR Fat tissue and a specific protein are crucial for healthy hair growth and maintenance.
    In the 2018 study by Sardella et al., it was demonstrated that adipose tissue and peroxisome proliferator-activated receptor gamma (PPARγ) are essential for hair follicle development and cycling. Using a global PPARγ-null mouse model, the researchers found that the absence of PPARγ led to delayed hair follicle morphogenesis, a slower hair cycle, shorter hair, and progressive hair loss beginning at 6 months of age. The mice also lacked sebaceous glands and exhibited total lipoatrophy. The study highlighted the importance of adipocytes in early hair follicle development and indicated that dysfunctional PPARγ signaling can adversely affect hair follicle stem cell regulation, sebaceous gland function, and increase skin inflammation. These results suggest that treatments for scarring alopecias should target PPARγ stimulation and address inflammation. The document also mentions a study by Ko et al. on thermal imaging for cellulitis diagnosis, but the number of participants is not specified.
    Discuss this study in the Community →

    Research cited in this study

    5 / 5 results

    Related Community Posts Join

    6 / 27 results
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 3 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community The Big Fat Layer II

      in Research/Science  26 upvotes 3 years ago
      Hair loss treatment should target dermal white adipose tissue (DWAT) to restore hair follicles. Potential remedies include tocopherol (vitamin E), botox, rosiglitazone, niacin, kojyl cinnamate esters, and ADP355.

      community Injecting stomach fat into the scalp could cure baldness in just six months

      in Update  114 upvotes 6 years ago
      A potential treatment for hair loss that involves injecting fat into the scalp; the role of testosterone and estrogen in thinning fat tissue under the skin; research on using lard to treat androgenic alopecia, as well as PRP + ACELL/amniotic stem cell treatments; and ongoing clinical trials by doctors involved in the study.

      community The Big Fat Layer / Remedies: Cetirizine

      in Treatment  12 upvotes 3 years ago
      Treating hair loss with various remedies, such as Cetirizine and the Big3 complex (minoxidil, finasteride, and RU58841), which have properties like adipogenic, anti-fibrotic and anti-inflammatory. References to research studies are also included.

      community Having androgen receptor density and sensitivity at wrong f*ing place

      in Satire  7 upvotes 1 month ago
      The conversation discusses hair loss treatments, focusing on the use of topical minoxidil, microneedling, finasteride, and dutasteride, while debating the role of testosterone and DHT in hair loss. It also touches on the potential liver health impacts of these treatments and the genetic sensitivity of hair follicles to androgens.

    Similar Research

    5 / 1000+ results