Early Skin Seeding Regulatory T Cells Modulate PPARγ-Dependent Skin Pigmentation

    October 2023 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    Inchul Cho, Jessie Z. Xu, Hafsah Aziz … Niwa Ali

    Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

    Studysummary This study found that neonatal Regulatory T cells are crucial for maintaining PPARγ signaling in hair follicles, which supports melanocyte stem cell function and skin pigmentation during early postnatal development.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 4

    1. Developing Human Skin Contains Lymphocytes Demonstrating a Memory Signature Cell Reports Medicine · 2020
    2. Commensal Microbes and Hair Follicle Morphogenesis Coordinately Drive Treg Migration into Neonatal Skin Cell host & microbe · 2017
    3. Cutting Edge: Memory Regulatory T Cells Require IL-7 and Not IL-2 for Their Maintenance in Peripheral Tissues ˜The œjournal of immunology/˜The œJournal of immunology · 2013
    4. Skin Melanocytes: Biology and Development Postepy Dermatologii I Alergologii · 2013