Peroxisome Proliferator Activated Receptor-Gamma Tissue Expression and Gene Polymorphism in Alopecia Areata in an Egyptian Sample

October 2023 in “ Benha Journal of Applied Sciences ”

Khaled Hussein, H.H. Sabry, Rehab Mohammed Salem, Nayira A. Abdel Baky, Hend Elsayed Nasr

Peroxisome Proliferator-Activated Receptor-Gamma PPAR-γ alopecia areata inflammatory skin conditions lipid metabolism immune response AA

TLDR PPAR-γ may be a key target for treating alopecia areata and other skin conditions.

This study on an Egyptian sample explored the role of Peroxisome Proliferator-Activated Receptor-Gamma (PPAR-γ) in alopecia areata (AA) with 10 participants, equally divided between AA patients and healthy controls. Significant differences in PPAR-γ tissue expression were observed between the groups, indicating its crucial role in AA pathogenesis. The findings suggest PPAR-γ as a potential therapeutic target for AA and other inflammatory skin conditions due to its regulatory effects on inflammation, lipid metabolism, and immune response.

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community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community You will lose hair if your prostaglandins aren't in balance

in Research/Science 55 upvotes 7 months ago

Prostaglandin balance affects hair loss, particularly in conditions like Lichen Planopilaris, where an imbalance can lead to hair follicle damage. Treatments mentioned include prostaglandin analogs and Pioglitazone HCL, with a focus on maintaining prostaglandin equilibrium for potential hair regrowth.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

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Peroxisome Proliferator Activated Receptor-Gamma Tissue Expression and Gene Polymorphism in Alopecia Areata in an Egyptian Sample

Related Community Posts Join

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

community You will lose hair if your prostaglandins aren't in balance

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

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