Peroxisome Proliferator Activated Receptor-Gamma Tissue Expression and Gene Polymorphism in Alopecia Areata in an Egyptian Sample

    October 2023 in “ Benha Journal of Applied Sciences ”
    Khaled Hussein, H.H. Sabry, Rehab Mohammed Salem, Nayira A. Abdel Baky, Hend Elsayed Nasr
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    TLDR PPAR-γ may be a key target for treating alopecia areata and other skin conditions.
    This study on an Egyptian sample explored the role of Peroxisome Proliferator-Activated Receptor-Gamma (PPAR-γ) in alopecia areata (AA) with 10 participants, equally divided between AA patients and healthy controls. Significant differences in PPAR-γ tissue expression were observed between the groups, indicating its crucial role in AA pathogenesis. The findings suggest PPAR-γ as a potential therapeutic target for AA and other inflammatory skin conditions due to its regulatory effects on inflammation, lipid metabolism, and immune response.
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