Epidermal PPARγ Is a Key Homeostatic Regulator of Cutaneous Inflammation and Barrier Function in Mouse Skin

August 2021 in “ International journal of molecular sciences ”

Raymond L. Konger, Ethel Derr‐Yellin, Teresa A. Zimmers, Terrence M. Katona, Xiaoling Xuei, Yunlong Liu, Hongming Zhou, Edward Simpson, Matthew J. Turner

PPARγ epidermal PPARγ cutaneous inflammation barrier function keratinization sebaceous gland function alopecia dandruff inflammatory skin lesions skin homeostasis PPAR gamma skin inflammation skin barrier hair loss skin flakes

TLDR PPARγ is essential for maintaining healthy skin, controlling inflammation, and ensuring proper skin barrier function.

The study investigates the role of epidermal PPARγ in maintaining skin homeostasis in mice, revealing that its loss leads to significant changes in gene expression related to inflammation, keratinization, and sebaceous gland function. Mice with epidermal-specific deletion of PPARγ exhibited increased skin inflammation, impaired barrier function, alopecia, dandruff, and spontaneous inflammatory skin lesions. The findings underscore the importance of PPARγ in regulating skin inflammation and barrier integrity, suggesting that targeting PPARγ could be a potential therapeutic strategy for treating inflammatory skin disorders and improving barrier function.

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