Epidermal PPARγ Is a Key Homeostatic Regulator of Cutaneous Inflammation and Barrier Function in Mouse Skin

The study investigates the role of epidermal PPARγ in maintaining skin homeostasis in mice, revealing that its loss leads to significant changes in gene expression related to inflammation, keratinization, and sebaceous gland function. Mice with epidermal-specific deletion of PPARγ exhibited increased skin inflammation, impaired barrier function, alopecia, dandruff, and spontaneous inflammatory skin lesions. The findings underscore the importance of PPARγ in regulating skin inflammation and barrier integrity, suggesting that targeting PPARγ could be a potential therapeutic strategy for treating inflammatory skin disorders and improving barrier function.