Epidermal PPARγ Is a Key Homeostatic Regulator of Cutaneous Inflammation and Barrier Function in Mouse Skin

August 2021 in “ International journal of molecular sciences ”

Raymond L. Konger, Ethel Derr‐Yellin, Teresa A. Zimmers, Terrence M. Katona, Xiaoling Xuei, Yunlong Liu, Hongming Zhou, Edward Simpson, Matthew J. Turner

PPARγ epidermal PPARγ cutaneous inflammation barrier function keratinization sebaceous gland function alopecia dandruff inflammatory skin lesions skin homeostasis PPAR gamma skin inflammation skin barrier hair loss skin flakes

Studysummary This study found that loss of epidermal PPARγ in mice altered the expression of many genes related to skin inflammation, keratinization, and sebaceous gland function, indicating its key role in maintaining skin homeostasis.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

View this study on mdpi.com →

Discuss this study in the Community →

Research cited in this study

10 / 10 results

research Sebaceous Gland Abnormalities in Fatty Acyl CoA Reductase 2 (Far2) Null Mice Result in Primary Cicatricial Alopecia

14 citations , October 2018 in “PloS one”

In this study, Far2-/- mice were observed to develop focal alopecia with altered sebaceous gland morphology and lower skin lipid levels compared to wildtype mice.

research PPAR-γ Agonists and Their Role in Primary Cicatricial Alopecia

38 citations , January 2017 in “PPAR Research”

This review discusses the role of PPAR-γ in the pathogenesis of primary cicatricial alopecia, including its involvement in lichen planopilaris and treatment trials using PPAR-agonists, and reports no new clinical results.

research Sebaceous Gland Atrophy in Psoriasis: An Explanation for Psoriatic Alopecia?

69 citations , June 2016 in “Journal of Investigative Dermatology”

This study found sebaceous gland atrophy and altered gene expression in psoriatic skin lesions, which may relate to the observed hair loss in these areas.

research Peroxisome Proliferator-Activated Receptors (PPARs) and PPAR Agonists: The Future in Dermatology Therapeutics?

60 citations , May 2015 in “Archives of dermatological research”

This review discusses the role of peroxisome proliferator-activated receptors and their agonists in dermatology but reports no new clinical results.

research The Role of PPARγ-Mediated Signalling in Skin Biology and Pathology: New Targets and Opportunities for Clinical Dermatology

84 citations , February 2015 in “Experimental Dermatology”

This review discusses the role of PPARs in skin health, suggesting both potential benefits and adverse effects, but reports no new experimental results; the authors emphasize the need for more research to understand these pathways.

research Role of Stearoyl-CoA Desaturase-1 in Skin Integrity and Whole Body Energy Balance

67 citations , December 2013 in “Journal of Biological Chemistry”

This review discusses the role of the enzyme Δ9-desaturase-1 in skin lipid regulation and whole-body energy balance in mice and reports no new experimental results.

research Normal Fur Development and Sebum Production Depend on Fatty Acid 2-Hydroxylase Expression in Sebaceous Glands

40 citations , June 2011 in “Journal of biological chemistry/The Journal of biological chemistry”

This study revealed that deficiency in the enzyme FA2H in mice affected sebaceous gland function, altered sebum composition, and caused cycling alopecia, highlighting FA2H's role in hair follicle homeostasis.

research The Human Keratins: Biology And Pathology

1398 citations , May 2008 in “Histochemistry and Cell Biology”

This review summarizes the cell type distribution and functional significance of human keratins, emphasizing their roles in tumor diagnosis and potential clinical applications, and reports no new clinical findings.

research Keratin 15 Promoter Targets Putative Epithelial Stem Cells in the Hair Follicle Bulge

387 citations , November 2003 in “Journal of Investigative Dermatology”

The K15 promoter effectively targets stem cells in the hair follicle bulge.

research Keratin 15 Expression in Stratified Epithelia: Downregulation in Activated Keratinocytes

198 citations , March 1999 in “Journal of Investigative Dermatology”

This study found that keratin 15 expression is downregulated in hyperproliferative conditions like psoriasis and hypertrophic scars, suggesting it is not compatible with keratinocyte activation.