Epidermal PPARγ Is a Key Homeostatic Regulator of Cutaneous Inflammation and Barrier Function in Mouse Skin

August 2021 in “ International journal of molecular sciences ”

Raymond L. Konger, Ethel Derr‐Yellin, Teresa A. Zimmers, Terrence M. Katona, Xiaoling Xuei, Yunlong Liu, Hongming Zhou, Edward Simpson, Matthew J. Turner

PPARγ epidermal PPARγ cutaneous inflammation barrier function keratinization sebaceous gland function alopecia dandruff inflammatory skin lesions skin homeostasis PPAR gamma skin inflammation skin barrier hair loss skin flakes

TLDR PPARγ is essential for maintaining healthy skin, controlling inflammation, and ensuring proper skin barrier function.

The study investigates the role of epidermal PPARγ in maintaining skin homeostasis in mice, revealing that its loss leads to significant changes in gene expression related to inflammation, keratinization, and sebaceous gland function. Mice with epidermal-specific deletion of PPARγ exhibited increased skin inflammation, impaired barrier function, alopecia, dandruff, and spontaneous inflammatory skin lesions. The findings underscore the importance of PPARγ in regulating skin inflammation and barrier integrity, suggesting that targeting PPARγ could be a potential therapeutic strategy for treating inflammatory skin disorders and improving barrier function.

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Research cited in this study

6 / 6 results

research Sebaceous Gland Abnormalities in Fatty Acyl CoA Reductase 2 (Far2) Null Mice Result in Primary Cicatricial Alopecia

14 citations, October 2018 in “PloS one”

Deleting the Far2 gene in mice causes sebaceous gland issues and patchy hair loss.

research PPAR-γ Agonists and Their Role in Primary Cicatricial Alopecia

38 citations, January 2017 in “PPAR Research”

PPAR-γ helps control skin oil glands and inflammation, and its disruption can cause hair loss diseases.

research Peroxisome Proliferator-Activated Receptors (PPARs) and PPAR Agonists: The Future in Dermatology Therapeutics?

60 citations, May 2015 in “Archives of dermatological research”

PPAR agonists show promise for skin conditions but need more research before being a main treatment.

research The Role of PPARγ-Mediated Signalling in Skin Biology and Pathology: New Targets and Opportunities for Clinical Dermatology

84 citations, February 2015 in “Experimental Dermatology”

PPARγ is crucial for skin health but can have both beneficial and harmful effects.

research Role of Stearoyl-CoA Desaturase-1 in Skin Integrity and Whole Body Energy Balance

67 citations, December 2013 in “Journal of Biological Chemistry”

SCD1 is crucial for skin health and overall energy balance.

research Normal Fur Development and Sebum Production Depend on Fatty Acid 2-Hydroxylase Expression in Sebaceous Glands

40 citations, June 2011 in “Journal of biological chemistry/The Journal of biological chemistry”

FA2H is essential for normal fur and sebum production in mice.

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