Epidermal PPARγ Is a Key Homeostatic Regulator of Cutaneous Inflammation and Barrier Function in Mouse Skin

    Raymond L. Konger, Ethel Derr‐Yellin, Teresa A. Zimmers … Matthew J. Turner
    Studysummary This study found that loss of epidermal PPARγ in mice altered the expression of many genes related to skin inflammation, keratinization, and sebaceous gland function, indicating its key role in maintaining skin homeostasis.
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    Research cited in this study 10

    1. Sebaceous Gland Abnormalities in Fatty Acyl CoA Reductase 2 (Far2) Null Mice Result in Primary Cicatricial Alopecia PloS one · 2018
    2. PPAR-γ Agonists and Their Role in Primary Cicatricial Alopecia PPAR Research · 2017
    3. Sebaceous Gland Atrophy in Psoriasis: An Explanation for Psoriatic Alopecia? Journal of Investigative Dermatology · 2016
    4. Peroxisome Proliferator-Activated Receptors (PPARs) and PPAR Agonists: The Future in Dermatology Therapeutics? Archives of dermatological research · 2015
    5. The Role of PPARγ-Mediated Signalling in Skin Biology and Pathology: New Targets and Opportunities for Clinical Dermatology Experimental Dermatology · 2015
    6. Role of Stearoyl-CoA Desaturase-1 in Skin Integrity and Whole Body Energy Balance Journal of Biological Chemistry · 2013
    7. Normal Fur Development and Sebum Production Depend on Fatty Acid 2-Hydroxylase Expression in Sebaceous Glands Journal of biological chemistry/˜The œJournal of biological chemistry · 2011
    8. The Human Keratins: Biology And Pathology Histochemistry and Cell Biology · 2008
    9. Keratin 15 Promoter Targets Putative Epithelial Stem Cells in the Hair Follicle Bulge Journal of Investigative Dermatology · 2003
    10. Keratin 15 Expression in Stratified Epithelia: Downregulation in Activated Keratinocytes Journal of Investigative Dermatology · 1999